Prezista (Darunavir) Patient Information: Missed a Dose and What Should I Avoid at RxList

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May 27, 2012

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Prezista Patient Information including If I Miss a Dose

What happens if I miss a dose (Prezista)?

Take the missed dose of darunavir and ritonavir as soon as you remember and take your next dose at the regularly scheduled time.

If you take darunavir 800 milligrams once daily and you are more than 12 hours late in taking your medications, skip the missed dose and take the next regularly scheduled dose. Do not take extra medicine to make up the missed dose.

If you take darunavir 600 milligrams twice daily and you are more than 6 hours late in taking your medications, skip the missed dose and take the next regularly scheduled dose.

Always take darunavir and ritonavir together. Do not take extra medicine to make up the missed dose.

What happens if I overdose (Prezista)?

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a darunavir overdose are unknown.

What should I avoid while taking darunavir (Prezista)?

If you also take didanosine, take it 1 hour before or 2 hours after you take darunavir.

Avoid having unprotected sex or sharing needles, razors, or toothbrushes. Taking this medication will not prevent you from passing HIV to other people. Talk with your doctor about safe methods of preventing HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

What other drugs will affect darunavir (Prezista)?

Many drugs can interact with darunavir. Below is just a partial list. Tell your doctor if you are using:

buprenorphine and naloxone (Suboxone);
methadone (Methadose, Dolophine, Diskets);
risperidone (Risperdal) or thioridazine (Mellaril);
an antibiotic such as clarithromycin (Biaxin), rifabutin (Mycobutin), or rifampin (Rifadin, Rimactane, Rifater);
an antifungal medication such as itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend);
an antidepressant such as desipramine (Norpramin), paroxetine (Paxil), sertraline (Zoloft), trazodone (Desyrel), and others;
beta-blockers such as metoprolol (Lopressor, Toprol) or timolol (Blocadren, Betimol, Cosopt, Timoptic);
a blood thinner such as warfarin (Coumadin);
a calcium channel blocker such as diltiazem (Cartia, Cardizem), felodipine (Plendil), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others;
cholesterol-lowering medicine such as atorvastatin (Lipitor) pravastatin (Pravachol), rosuvastatin (Crestor);
drugs that weaken the immune system, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Prograf);
a heart rhythm medication such as amiodarone (Cordarone), digoxin (digitalis, Lanoxin), flecainide (Tambocor), lidocaine, propafenone (Rythmol), or quinidine (Quinaglute, Quinidex);
insulin or diabetes medication you take by mouth;
medicines to treat erectile dysfunction, such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra);
other HIV /AIDS medicine such as efavirenz (Sustiva), lopinavir/ritonavir (Kaletra), or saquinavir (Invirase, Fortovase);
seizure medications such as carbamazepine (Carbatrol, Tegretol), phenobarbital (Luminal, Solfoton), or phenytoin (Dilantin); or
a steroid medication such as dexamethasone (Decadron, Hexadrol) or fluticasone (Advair, Flonase, Flovent).

This list is not complete and there are many other medicines that can interact with darunavir. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about darunavir.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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