August 24, 2016
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Prezista Patient Information including If I Miss a Dose

What happens if I miss a dose (Prezista)?

Take the missed dose of darunavir and ritonavir as soon as you remember and take your next dose at the regularly scheduled time.

If you take darunavir 800 milligrams once daily and you are more than 12 hours late in taking your medications, skip the missed dose and take the next regularly scheduled dose. Do not take extra medicine to make up the missed dose.

If you take darunavir 600 milligrams twice daily and you are more than 6 hours late in taking your medications, skip the missed dose and take the next regularly scheduled dose.

Always take darunavir and ritonavir together. Do not take extra medicine to make up the missed dose.

What happens if I overdose (Prezista)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking darunavir (Prezista)?

If you also take didanosine (Videx), take it 1 hour before or 2 hours after you take darunavir.

Taking this medication will not prevent you from passing HIV to other people. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

What other drugs will affect darunavir (Prezista)?

Many drugs can interact with darunavir. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with darunavir, especially:

  • atorvastatin;
  • buprenorphine and naloxone;
  • colchicine;
  • methadone;
  • risperidone or thioridazine;
  • salmeterol ;
  • an antibiotic or antifungal medication;
  • an antidepressant such as desipramine, trazodone, and others;
  • any other HIV/AIDS medicines;
  • a blood thinner such as warfarin, Coumadin;
  • heart or blood pressure medicine such as felodipine, metoprolol, nicardipine, nifedipine, timolol, and others;
  • drugs that weaken the immune system, such as cyclosporine, sirolimus, or tacrolimus;
  • a heart rhythm medication such as amiodarone, digoxin (digitalis), flecainide, lidocaine, propafenone, or quinidine;
  • insulin or diabetes medication you take by mouth;
  • medicines to treat erectile dysfunction, such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra);
  • seizure medications such as carbamazepine, phenobarbital, or phenytoin;
  • the hepatitis C medications boceprevir or telaprevir; or
  • steroids (oral, nasal, inhaled, or injectable).

This list is not complete and many other drugs can interact with darunavir. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about darunavir.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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