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(rifapentine) Tablets for Oral Administration
PRIFTIN (rifapentine) for oral administration contains 150 mg of the active ingredient rifapentine per tablet.
The 150 mg tablets also contain, as inactive ingredients: calcium stearate, disodium EDTA, FD&C Blue No. 2 aluminum lake, hydroxypropyl cellulose, hypromellose USP, microcrystalline cellulose, polyethylene glycol, pregelatinized starch, propylene glycol, sodium ascorbate, sodium lauryl sulfate, sodium starch glycolate, synthetic red iron oxide, and titanium dioxide.
Rifapentine is a rifamycin derivative antimicrobial and has a similar profile of microbiological activity to rifampicin. The molecular weight is 877.04.
The molecular formula is C47H64N4O12.
The chemical name for rifapentine is rifamycin, 3-[[(4-cyclopentyl-1-piperazinyl)imino]methyl]or 3-[N-(4-Cyclopentyl -1-piperazinyl)formimidoyl] rifamycin or 5,6,9,17,19,21-hexahydroxy23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-[N-(4-cyclopentyl-l-piperazinyl)-formimidoyl]2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione 21-acetate. It has the following structure:
What are the possible side effects of rifapentine (Priftin)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- blood in your urine;
- pale skin, weakness, easy bruising or bleeding; or
- fever, chills, body aches, flu symptoms.
Less serious side effects may include:
- red, orange, or brown discoloration of your skin, tears, sweat, saliva, urine, or stools;
- nausea, vomiting, diarrhea, loss of...
What are the precautions when taking rifapentine (Priftin)?
Before taking rifapentine, tell your doctor or pharmacist if you are allergic to it; or to other rifamycins (such as rifampin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: HIV infection, a certain blood disorder (porphyria), liver disease, alcohol use.
Alcohol may increase the risk of liver disease. Avoid alcoholic beverages while using this medication.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Rifapentine may cause...
Last reviewed on RxList: 12/16/2014
This monograph has been modified to include the generic and brand name in many instances.
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