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Active Pulmonary Tuberculosis
PRIFTIN® (rifapentine) is indicated in adults and children 12 years and older for the treatment of active pulmonary tuberculosis (TB) caused by Mycobacterium tuberculosis. PRIFTIN must always be used in combination with one or more antituberculosis (anti-TB) drugs to which the isolate is susceptible [see DOSAGE AND ADMINISTRATION and Clinical Studies].
Limitations of Use
Do not use PRIFTIN monotherapy in either the initial or the continuation phases of active antituberculous treatment.
PRIFTIN should not be used once-weekly in the continuation phase regimen in combination with isoniazid (INH) in HIV-infected patients with active pulmonary tuberculosis because of a higher rate of failure and/or relapse with rifampin (RIF)-resistant organisms [see WARNINGS AND PRECAUTIONS and Clinical Studies].
PRIFTIN has not been studied as part of the initial phase treatment regimen in HIV-infected patients with active pulmonary tuberculosis.
Latent Tuberculosis Infection
PRIFTIN is indicated in adults and children 2 years and older for the treatment of latent tuberculosis infection caused by Mycobacterium tuberculosis in patients at high risk of progression to tuberculosis disease (including those in close contact with active tuberculosis patients, recent conversion to a positive tuberculin skin test, HIV-infected patients, or those with pulmonary fibrosis on radiograph) [see Clinical Studies].
Limitations of Use
Active tuberculosis disease should be ruled out before initiating treatment for latent tuberculosis infection.
PRIFTIN must always be used in combination with isoniazid as a 12-week once-weekly regimen for the treatment of latent tuberculosis infection. [see DOSAGE AND ADMINISTRATION and Clinical Studies]
- PRIFTIN in combination with isoniazid is not recommended for Individuals presumed to be exposed to rifamycin-or -isoniazid resistant M. tuberculosis.
DOSAGE AND ADMINISTRATION
Dosage In Active Pulmonary Tuberculosis
PRIFTIN is only recommended for the treatment of active pulmonary tuberculosis caused by drug-susceptible organisms as part of regimens consisting of a 2 month initial phase followed by a 4 month continuation phase. PRIFTIN should not be used in the treatment of active pulmonary tuberculosis caused by rifampin-resistant strains.
Initial phase (2 Months)
PRIFTIN should be administered at a dose of 600 mg twice weekly for two months as directly observed therapy (DOT), with an interval of no less than 3 consecutive days (72 hours) between doses, in combination with other anti-tuberculosis drugs as part of an appropriate regimen which includes daily companion drugs such as isoniazid (INH), ethambutol (EMB) and pyrazinamide (PZA).
Continuation phase (4 Months)
Following the initial phase (2 months), continuation phase (4 months) treatment consists of PRIFTIN 600 mg once-weekly for 4 months in combination with isoniazid or another appropriate anti-tuberculosis agent for susceptible organisms administered as directly observed therapy.
Dosage In Latent Tuberculosis Infection
PRIFTIN should be administered once-weekly in combination with isoniazid for 12 weeks as directly observed therapy.
Adults and children 12 years and older
The recommended dose of PRIFTIN should be determined based on weight of the patient up to a maximum of 900 mg once-weekly (see Table 1). The recommended dose of isoniazid is 15 mg/kg (rounded to the nearest 50 mg or 100mg) up to a maximum of 900 mg once-weekly for 12 weeks.
Children 2-11 years
The recommended dose of PRIFTIN should be determined based on weight of the patient up to a maximum of 900 mg once-weekly (see Table 1). The recommended dose of isoniazid is 25 mg/kg (rounded to the nearest 50 mg or 100mg) up to a maximum of 900 mg once-weekly for 12 weeks.
Table 1: Weight based dose of PRIFTIN in the treatment
of latent tuberculosis infection
|Weight range||PRIFTIN dose||Number of PRIFTIN tablets|
|10-14 kg||300 mg||2|
|14.1-25 kg||450 mg||3|
|25.1-32 kg||600 mg||4|
|32.1-50 kg||750 mg||5|
|> 50 kg||900 mg||6|
Take PRIFTIN with meals. Administration of PRIFTIN with a meal increases oral bioavailability and may reduce the incidence of gastrointestinal upset, nausea, and/or vomiting. [see CLINICAL PHARMACOLOGY].
For patients who cannot swallow tablets, the tablets may be crushed and added to a small amount of semi-solid food, all of which should be consumed immediately [see CLINICAL PHARMACOLOGY].
Dosage Forms And Strengths
PRIFTIN is supplied as 150 mg round normal convex dark-pink film-coated tablets debossed “Priftin” on top and “150” on the bottom.
Storage And Handling
PRIFTIN is supplied as 150 mg round normal convex dark-pink film-coated tablets debossed “Priftin” on top and “150” on the bottom, packaged in aluminum formable foil blister strips inserted into an aluminum foil laminated pouch.
Carton of 32 tablets (4 strips of 8 tablets) NDC
Carton of 24 tablets (3 strips of 8 tablets) NDC 0088-2100-XX
Store at 25°C (77°F); excursions permitted 15-30°C (59-86°F) (see USP Controlled Room Temperature). Protect from excessive heat and humidity.
Manufactured by: sanofi-aventis U.S. LLC, Bridgewater, NJ 08807. Revised: November 2014This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 12/16/2014
Additional Priftin Information
Report Problems to the Food and Drug Administration
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