Prilosec (Omeprazole) Drug Information: Overdosage and Contraindications

Pill Identifier Search

May 27, 2012

Prilosec

Helicobacter Pylori (H pylori) »

What is Helicobacter pylori?

Helicobacter pylori (H. pylori) is a bacterium that causes chronic inflammation of the inner lining of the stomach (gastritis) in humans. This bacterium also is considered as a common cause of ulcers worldwide; as many as 90% of people with ulcers have detectable organisms.

H. pylori infection is most likely acquired by ingesting contaminated food and water, and through person to person contact. In the United States, about 30% of the adult population is infected (50% of infected persons are infected by the age of 60), but the prevalence of infection is decreasing because there is increasing awareness about the infection, and treatment is common. About 50% of the world population is estimated to have detectable H. pylori in their gastrointestinal tract (GI tract, but stomach, mainly).

The infection is more common in crowded living conditions with poor sanitation. In countries with poor sanit...

Read the Helicobacter Pylori (H pylori) article »

« Previous
1
2
3
4
5
6
7
8
9
10
11
12
13
Next »

Prilosec User Reviews >>

Prilosec

Heartburn: Foods to Eat, Foods to Avoid Slideshow Pictures

Digestive Disease Myths Slideshow Pictures

Diverticulitis (Diverticulosis) Slideshow Pictures

font size

OVERDOSE

Reports have been received of overdosage with omeprazole in humans. Doses ranged up to 2400 mg (120 times the usual recommended clinical dose). Manifestations were variable, but included confusion, drowsiness, blurred vision, tachycardia, nausea, vomiting, diaphoresis, flushing, headache, dry mouth, and other adverse reactions similar to those seen in normal clinical experience. [See ADVERSE REACTIONS] Symptoms were transient, and no serious clinical outcome has been reported when PRILOSEC was taken alone. No specific antidote for omeprazole overdosage is known. Omeprazole is extensively protein bound and is, therefore, not readily dialyzable. In the event of overdosage, treatment should be symptomatic and supportive.

As with the management of any overdose, the possibility of multiple drug ingestion should be considered. For current information on treatment of any drug overdose, contact a Poison Control Center at 1800-222-1222.

Single oral doses of omeprazole at 1350, 1339, and 1200 mg/kg were lethal to mice, rats, and dogs, respectively. Animals given these doses 16 showed sedation, ptosis, tremors, convulsions, and decreased activity, body temperature, and respiratory rate and increased depth of respiration.

CONTRAINDICATIONS

PRILOSEC (omeprazole) Delayed-Release Capsules are contraindicated in patients with known hypersensitivity to substituted benzimidazoles or to any component of the formulation. Hypersensitivity reactions may include anaphylaxis, anaphylactic shock, angioedema, bronchospasm, interstitial nephritis, and urticaria [See ADVERSE REACTIONS].

Last reviewed on RxList: 3/15/2011
This monograph has been modified to include the generic and brand name in many instances.