Recommended Topic Related To:

Primaquine

"Jan. 24, 2013 -- The flu is not the only highly contagious disease raging this winter.

A new strain of norovirus is causing intestinal illness outbreaks across the country, the CDC confirmed today.

Norovirus is often to blame when "...

Primaquine




Overdosage
Contraindications

OVERDOSE

Symptoms of overdosage of primaquine phosphate are similar to those seen after overdosage of pamaquine. They include abdominal cramps, vomiting, burning epigastric distress, central nervous system and cardiovascular disturbances, cyanosis, methemoglobinemia, moderate leukocytosis or leukopenia, and anemia. The most striking symptoms are granulocytopenia and acute hemolytic anemia in sensitive persons. Acute hemolysis occurs, but patients recover completely if the dosage is discontinued.

CONTRAINDICATIONS

Primaquine phosphate is contraindicated in acutely ill patients suffering from systemic disease manifested by tendency to granulocytopenia, such as rheumatoid arthritis and lupus erythematosus. The drug is also contraindicated in patients receiving concurrently other potentially hemolytic drugs or depressants of myeloid elements of the bone marrow.

Because quinacrine hydrochloride appears to potentiate the toxicity of antimalarial compounds which are structurally related to primaquine (phosphate tablets) , the use of quinacrine in patients receiving primaquine (phosphate tablets) is contraindicated. Similarly, Primaquine (phosphate tablets) should not be administered to patients who have received quinacrine recently, as toxicity is increased.

Last reviewed on RxList: 9/25/2008
This monograph has been modified to include the generic and brand name in many instances.

Overdosage
Contraindications
A A A

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Women's Health

Find out what women really need.