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Primaquine Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Primaquine phosphate is an antimalarial drug prescribed to treat and prevent malaria. It is available in generic form. Common side effects of Primaquine include nausea, stomach pain or upset, vomiting, loss of appetite, heartburn, and abdominal cramps.
The recommended dosage of Primaquine is one tablet daily for 14 days. Primaquine may interact with other drugs. Do not take Primaquine if you have recently taken Atabrine (quinacrine), have severe rheumatoid arthritis, lupus, or are taking some anti-cancer drugs. Tell your doctor all medications you are taking. Do not drive, use machinery, or do any activity that requires alertness when taking Primaquine. Talk to your doctor if you are pregnant or breastfeeding before taking Primaquine.
Our Primaquine phosphate Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Primaquine in Detail - Patient Information: Side Effects
Stop taking primaquine and seek emergency medical attention if you experience an allergic reaction (flushing; swelling of your lips, tongue, or face, difficulty breathing; closing of your throat; vision problems; a rash; or itching).
Notify your doctor if you experience darkening of your urine.
Nausea, stomach pain or upset, vomiting, and loss of appetite may also occur during therapy.
Read the entire detailed patient monograph for Primaquine (Phosphate Tablets)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Primaquine Overview - Patient Information: Side Effects
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor immediately if any of these rare but very serious side effects occur: signs of serious infection (such as high fever, severe chills, persistent sore throat), signs of a sudden loss of red blood cells (such as severe tiredness, brown urine, pale lips/nails/skin, fast heartbeat/breathing with usual activities), signs of a certain blood problem (methemoglobinemia, including bluish skin/lips/nails, headache, shortness of breath, lightheadedness, weakness, confusion, chest pain, sudden pounding heartbeat).
Get medical help right away if any of these rare but serious side effects occur: fast/irregular heartbeat, severe dizziness, fainting.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Primaquine (Phosphate Tablets)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Primaquine FDA Prescribing Information: Side Effects
Gastrointestinal: nausea, vomiting, epigastric distress, and abdominal cramps.
Hematologic: leukopenia, hemolytic anemia in glucose-6-phosphate dehydrogenase (G-6-PD) deficient individuals, and methemoglobinemia in nicotinamide adenine dinucleotide (NADH) methemoglobin reductase deficient individuals.
Read the entire FDA prescribing information for Primaquine (Phosphate Tablets)
Additional Primaquine Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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