Primary Biliary Cirrhosis (PBC)
Benjamin Wedro, MD, FACEP, FAAEM
Dr. Ben Wedro practices emergency medicine at Gundersen Clinic, a regional trauma center in La Crosse, Wisconsin. His background includes undergraduate and medical studies at the University of Alberta, a Family Practice internship at Queen's University in Kingston, Ontario and residency training in Emergency Medicine at the University of Oklahoma Health Sciences Center.
Bhupinder S. Anand, MBBS, MD, DPHIL (OXON)
Dr. Anand received MBBS degree from Medical College Amritsar, University of Punjab. He completed his Internal Medicine residency at the Postgraduate Institute of medical Education and Research, Chandigarh, India. He was trained in the field of Gastroenterology and obtained the DPhil degree. Dr. Anand is board-certified in Internal Medicine and Gastroenterology.
- Primary biliary cirrhosis (PBC) definition
- What are the causes of primary biliary cirrhosis?
- What are the risk factors for primary biliary cirrhosis?
- What are the signs and symptoms for primary biliary cirrhosis?
- How is the diagnosis of primary biliary cirrhosis made?
- What is the treatment for primary biliary cirrhosis?
- What are the complications of primary biliary cirrhosis?
- Can primary biliary cirrhosis be prevented?
- What is the prognosis for someone with primary biliary cirrhosis?
- Find a local Gastroenterologist in your town
Primary biliary cirrhosis (PBC) definition
Primary biliary cirrhosis (PBC) is a progressive disease of the liver caused by a buildup of bile within the liver (cholestasis) that results in damage to the small bile ducts that drain bile from the liver. Over time, this pressure build-up destroys the bile ducts leading to liver cell damage. As the disease progresses and enough liver cells die, cirrhosis and liver failure occur.
Bile is manufactured in the liver and then transported through the bile ducts to the gallbladder and intestine where it helps digest fats and fat soluble vitamins (A,D,E,K). When bile cannot be drained from the liver, it causes inflammation that leads to cell death. Scar tissue gradually replaces the areas of damaged liver and then the body cannot perform necessary functions.
What are the causes of primary biliary cirrhosis?
What are the risk factors for primary biliary cirrhosis?
- There may be a genetic component to the development of PBC since a person with the disease is likely to have a family member also afflicted.
- Women are nine times more likely than men to develop PBC. It most often develops in the middle age between the ages of 40 to 60.
- The disease is seen more often in white, northern Europeans, compared to African-Americans.
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