Slideshows Images Quizzes

Principen

Last reviewed on RxList: 1/26/2017
Principen Side Effects Center

Last reviewed on RxList 11/30/2016

Principen (ampicillin) is a penicillin-type antibiotic used to treat many different types of infections caused by bacteria, such as ear infections, bladder infections, pneumonia, gonorrhea, and E. coli or salmonella infection. Principen is available in generic form. Common side effects of Principen include:

  • nausea,
  • vomiting,
  • stomach pain,
  • diarrhea,
  • vaginal itching or discharge,
  • headache,
  • mouth/tongue sores,
  • thrush (white patches inside your mouth or throat), or
  • swollen, black, or "hairy" tongue.

Tell your doctor if you have rare but very serious side effects of Principen including:

  • dark urine,
  • persistent nausea or vomiting,
  • yellowing eyes or skin,
  • easy bruising or bleeding, or
  • persistent sore throat or fever.

The usual oral dose range of Principen for most infections is 250 to 500 mg 4 times daily for 7-14 days. To treat gonorrhea, a single 3.5 g dose is administered along with probenecid. Principen may interact with allopurinol, methotrexate, sulfa drugs, or tetracycline antibiotics. Tell your doctor all medications you are taking. Principen should be used only when prescribed during pregnancy. This medication passes into breast milk. Consult your doctor before breastfeeding.

Our Principen (ampicillin) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Principen Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
  • diarrhea that is watery or bloody;
  • fever, chills, body aches, flu symptoms;
  • easy bruising or bleeding, unusual weakness;
  • urinating less than usual or not at all;
  • agitation, confusion, unusual thoughts or behavior; or
  • seizure (black-out or convulsions).

Less serious side effects may include

  • nausea, vomiting, stomach pain;
  • vaginal itching or discharge;
  • headache;
  • swollen, black, or "hairy" tongue; or
  • thrush (white patches or inside your mouth or throat).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Principen (Ampicillin)

Principen Professional Information

SIDE EFFECTS

As with other penicillins, it may be expected that untoward reactions will be essentially limited to sensitivity phenomena. They are more likely to occur in individuals who have previously demonstrated hypersensitivity to penicillin and in those with a history of allergy, asthma, hay fever, or urticaria.

The following adverse reactions have been reported as associated with the use of ampicillin:

Gastrointestinal: glositis, stamatitis, nausea, vomiting, enterocolitis, pseudomembranous colitis, and diarrhea. These reactions are usually associated with oral dosage forms of the drugs.

Hypersensitivity Reactions: An erythematous, mildly pruritic, maculopapular skin rash has been reported fairly frequently. The rash, which usually does not develop within the first week of therapy, may cover the entire body including the soles, palms, and oral mucosa. The eruption usually disappears in three to seven days.

Other hypersensitivity reactions that have been reported are: skin rash, pruritus, urticaria, erythema multiforme, and an occasional case of exfoliative dermatitis. Anaphylaxis is the most serious reaction experienced and has usually been associated with the parenteral dosage form of the drug

Note: Urticaria, other skin rashes, and serum sickness-like reactions may be controlled by antihistamines, and if necessary, systemic corticosteroids. Whenever such reactions occur, ampicillin should be discontinued unless, in the opinion of the physician, the condition being treated is life-threatening, and amenable only to ampicillin therapy. Serious anaphylactoid reactions require emergency measures (see WARNINGS).

Liver: Moderate elevation in serum glutamic oxalaacetic transaminase (SGOT) has been noted, but the significance of this finding is unknown.

Hemic and Lymphatic Systems: Anemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leukapenia, and agranulacytosis have been reported during therapy with penicillins. These reactions are usually reversible on discontinuation of therapy and are believed to be hypersensitivity phenomena.

Other: Other adverse reactions that have been reported with the use at ampicillin are laryngeal stride and high fever. An occasional patient may complain of sore mouth or tongue as with any oral penicillin preparation.

Read the entire FDA prescribing information for Principen (Ampicillin)

Related Resources for Principen

© Principen Patient Information is supplied by Cerner Multum, Inc. and Principen Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

Health Solutions From Our Sponsors