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Following a single oral dose of 20 g/kg, no lethality occurred in rats and death occurred in one of 20 mice receiving the same dose. The most likely manifestation of overdosage would be hypotension, for which the usual treatment would be intravenous infusion of normal saline solution.
PRINIVIL is contraindicated in patients with:
- a history of angioedema or hypersensitivity related to previous treatment with an angiotensin converting enzyme inhibitor
- hereditary or idiopathic angioedema. Do not co-administer aliskiren with PRINIVIL in patients with diabetes [see DRUG INTERACTIONS].
Last reviewed on RxList: 8/26/2015
This monograph has been modified to include the generic and brand name in many instances.
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