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PrismaSol Solution

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PrismaSol Solution

PrismaSol Solution (sterile hemofiltration hemodiafiltration solution)
PrismaSol BGK 4/2.5
PrismaSol BGK 4/0/1.2
PrismaSol BK 0/0/1.2
PrismaSol BGK 2/3.5
PrismaSol BGK 2/0
PrismaSol BK 0/3.5
PrismaSol BGK 0/2.5
PrismaSol B22GK 4/0
PrismaSol B22GK 4/2.5
PrismaSol B22GK 2/0

Sterile Hemofitration and Hemodiafiltration Solution

DRUG DESCRIPTION

PrismaSol solution (sterile hemofiltration hemodiafiltration solution) is a clear, sterile solution free of bacterial endotoxins. This solution is used in Continuous Renal Replacement Therapies (CRRT) as a replacement solution in hemofiltration and hemodiafiltration.

It contains no bacteriostatic or antimicrobial agents.

PrismaSol solution (sterile hemofiltration hemodiafiltration solution) is packaged in a two-compartment bag. The small compartment A contains electrolytes and the large compartment B contains buffer. The final reconstituted solution (5000 mL) is obtained after breaking the red frangible pin between compartments A and B and mixing both solutions. The compositions of the solution before and after reconstitution are described in the following tables.

BEFORE RECONSTITUTION

1000 mL of electrolyte solution (small compartment A) contains (g)

  PrismaSol
BGK 4/2.5
PrismaSol
BGK 2/3.5
PrismaSol
BGK 0/2.5
PrismaSol
B22GK 4/2.5
Calcium chloride•2H2O 3.68 5.15 3.68 3.68
Magnesium chloride•6H2O 3.05 2.03 3.05 3.05
Dextrose anhydrous 20.0 20.0 20.0 20.0
(as dextrose monohydrate) 22.0 22.0 22.0 22.0
Lactic acid 5.40 5.40 5.40 5.40

1000mL of buffer solution (large compartment B) contains (g)

  PrismaSol
BGK 4/2.5
PrismaSol
BGK 2/3.5
PrismaSol
BGK 0/2.5
PrismaSol
B22GK 4/2.5
Sodium chloride 6.46 6.46 6.46 7 .07
Sodium bicarbonate 3.09 3.09 3.09 2.21
Potassium chloride 0.314 0.157 0 0.314

1000 mL of electrolyte solution (small compartment A) contains (g)

  PrismaSol
BGK4/0/1.2
PrismaSol
BGK 2/0
PrismaSol
B22GK4/0
PrismaSol
B22GK 2/0
PrismaSol
BK 0/0/1.2
PrismaSol
BK 0/3.5
Calcium chloride•2H2O 0 0 0 0 0 5.15
Magnesium chloride•6H2O 2.44 2.03 3.05 3.05 2.44 2.03
Dextrose anhydrous 20.0 20.0 20.0 20.0 0 0
(as dextrose monohydrate) 22.0 22.0 22.0 22.0 0 0
Lactic acid 5.40 5.40 5.40 5.40 5.40 5.40

1000 mL of buffer solution (large compartment B) contains (g)

  PrismaSol
BGK4/0/1.2
PrismaSol
BGK 2/0
PrismaSol
B22GK 4/0
PrismaSol
B22GK 2/0
PrismaSol
BK 0/0/1.2
PrismaSol
BK 0/3.5
Sodium chloride 6.46 6.46 7.07 7.07 6.46 6.46
Sodium bicarbonate 3.09 3.09 2.21 2.21 3.09 3.09
Potassium chloride 0.314 0.157 0.314 0.157 0 0

AFTER RECONSTITUTION of compartments A and B

1000 mL of the reconstituted solution contains

in mEq/L except where noted PrismaSol
BGK 4/2.5
PrismaSol
BGK 2/3.5
PrismaSol
BGK 0/2.5
PrismaSol
B22GK 4/2.5
CalciumCa2+ 2.5 3.5 2.5 2.5
Bicarbonate HCO3 32 32 32 22
Potassium K+ 4.0 2.0 0 4.0
Magnesium Mg2+ 1.5 1.0 1.5 1.5
Sodium Na+ 140 140 140 1140
Chloride Cl 113 111.5 109 123
Lactate 3.0 3.0 3.0 3.0
Dextrose 100 mg/dL 100 mg/dL 100 mg/dL 100 mg/dL
Theoretical 300 mOsm/L 296 mOsm/L 292 mOsm/L 300 mOsm/L

in mEq/L except where noted PrismaSol
BGK 4/0/1.2
PrismaSol
BGK 2/0
PrismaSol
B22GK 4/0
PrismaSol
B22GK 2/0
Calcium Ca2+ 0 0 0 0
Bicarbonate HCO3 32 32 22 22
Potassium K+ 4.0 2.0 4.0 2.0
Magnesium Mg2+ 1.2 1.0 1.5 1.5
Sodium Na+ 140 140 140 140
Chloride Cl 110.2 108 120.5 118.5
Lactate 3.0 3.0 3.0 3.0
Dextrose 100 mg/dL 100 mg/dL 100 mg/dL 100 mg/dL
Theoretical Osmolarity 295 mOsm/L 295 mOsm/L 295 mOsm/L 295 mOsm/L

In mEq/L except where noted PrismaSol
BK 0/0/1.2
PrismaSol
BK 0/3.5
Calcium Ca2+ 0 3.5
Bicarbonate HCO3 32 32
Potassium K+ 0 0
Magnesium Mg2+ 1.2 1.0
Sodium Na+ 140 140
Chloride Cl ,106.2 109.5
Lactate 3.0 3.0
Dextrose 0 0
Theoretical Osmolarity 282 mOsm/L 287 mOsm/L

Calcium chloride, USP, is chemically designated calcium chloride dihydrate (CaCl2•2 H2O).
Magnesium chloride, USP, is chemically designated magnesium chloride hexahydrate (MgCl2•6H2O).
Dextrose, USP, is chemically designated D-Glucose anhydrous (C6H12O6) or D-Glucose monohydrate (C6H12O6•H2O).
Lactic acid, USP, is chemically designated CH3CH(OH)COOH.
Sodium chloride, USP, is chemically designated NaCl.
Potassium chloride, USP, is chemically designated KCl.
Sodium bicarbonate, USP, is chemically designated NaHCO3.

The pH of the final solution is in the range of 7.0 to 8.5.

Solutions in contact with the plastic container can leach out certain of its chemical components in very small amounts within the expiration period, e.g. di 2-ethylhexyl phthalate (DEHP), up to 3 parts per milion; however, the safety of the plastic has been confirmed in tests in animals according to USP biological tests for plastic containers as well as by in-vitro toxicity studies.

Last reviewed on RxList: 12/29/2008
This monograph has been modified to include the generic and brand name in many instances.

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