"The U.S. Food and Drug Administration today proposed to withdraw approval of the drug midodrine hydrochloride, used to treat the low blood pressure condition orthostatic hypotension, because required post-approval studies that verify the clinical"...
Patients should be told that certain agents in over-the-counter products, such as cold remedies and diet aids, can elevate blood pressure, and therefore, should be used cautiously with ProAmatine® (midodrine hydrochloride) , as they may enhance or potentiate the pressor effects of ProAmatine® (see DRUG INTERACTIONS). Patients should also be made aware of the possibility of supine hypertension. They should be told to avoid taking their dose if they are to be supine for any length of time, i.e., they should take their last daily dose of ProAmatine® (midodrine hydrochloride) 3 to 4 hours before bedtime to minimize nighttime supine hypertension.
Laboratory Tests: Since desglymidodrine is eliminated by the kidneys and the liver has a role in its metabolism, evaluation of the patient should include assessment of renal and hepatic function prior to initiating therapy and subsequently, as appropriate.
Last reviewed on RxList: 10/25/2010
This monograph has been modified to include the generic and brand name in many instances.
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