Probenecid and Colchicine

Probenecid and Colchicine
Tablets USP

DRUG DESCRIPTION

Probenecid and colchicine contains probenecid, which is a uricosuric agent, and colchicine, which has antigout activity, the mechanism of which is unknown.

Probenecid is the generic name for 4-[(dipropylamino) sulfonyl] benzoic acid. The structural formula is represented below:

Probenecid and Colchicine Tablets USP Structural Formula Illustration

C13H19NO4S....................M.W. 285.36

Probenecid is a white or nearly white, fine, crystalline powder. It is soluble in dilute alkali, in alcohol, in chloroform, and in acetone; it is practically insoluble in water and in dilute acids.

Colchicine is an alkaloid obtained from various species of Colchicum. The chemical name for colchicine is (S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[α]heptalen-7-yl) acetamide. The structural formula is represented below:

Probenecid and Colchicine Tablets USP Structural Formula Illustration

C22H25NO6.................................M.W. 399.44

Colchicine consists of pale yellow scales or powder; it darkens on exposure to light. Colchicine is soluble in water, freely soluble in alcohol and in chloroform, and slightly soluble in ether. Each tablet for oral administration contains 500 mg of probenecid and 0.5 mg of colchicine.

Each tablet also contains the following inactive ingredients: colloidal silicon dioxide, magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate and sodium starch glycolate.

What are the possible side effects of colchicine and probenecid ()?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using colchicine and probenecid and call your doctor at once if you have any of these serious side effects:

  • painful urination, severe pain in your lower back or side;
  • easy bruising or bleeding, unusual weakness; or
  • severe diarrhea, nausea, vomiting, or stomach pain.

Continue using colchicine and probenecid and talk with your doctor if you have any of these less serious...

Read All Potential Side Effects and See Pictures of Probenecid and Colchicine »

Last reviewed on RxList: 9/29/2008
This monograph has been modified to include the generic and brand name in many instances.

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