Probenecid and Colchicine (Probenecid and Colchicine) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 9, 2012

Probenecid and Colchicine

Gout »

What is gout? What is hyperuricemia?

Gout is a disease that results from an overload of uric acid in the body. This overload of uric acid leads to the formation of tiny crystals of urate that deposit in tissues of the body, especially the joints. When crystals form in the joints, it causes recurring attacks of joint inflammation (arthritis). Gout is considered a chronic and progressive disease. Chronic gout can also lead to deposits of hard lumps of uric acid in the tissues, particularly in and around the joints and may cause joint destruction, decreased kidney function, and kidney stones (nephrolithiasis).

Gout has the unique distinction of being one of the most frequently recorded medical illnesses throughout history. It is often related to an inherited abnormality in the body's ability to process uric acid. Uric acid is a breakdown product of purines that are part of many foods we eat. An abnormality in handling uric acid can cause attacks of p...

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Probenecid and Colchicine

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Probenecid and Colchicine
Tablets USP

DRUG DESCRIPTION

Probenecid and colchicine contains probenecid, which is a uricosuric agent, and colchicine, which has antigout activity, the mechanism of which is unknown.

Probenecid is the generic name for 4-[(dipropylamino) sulfonyl] benzoic acid. The structural formula is represented below:

Probenecid and Colchicine Tablets USP Structural Formula Illustration

C₁₃H₁₉NO₄S....................M.W. 285.36

Probenecid is a white or nearly white, fine, crystalline powder. It is soluble in dilute alkali, in alcohol, in chloroform, and in acetone; it is practically insoluble in water and in dilute acids.

Colchicine is an alkaloid obtained from various species of Colchicum. The chemical name for colchicine is (S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[α]heptalen-7-yl) acetamide. The structural formula is represented below:

C₂₂H₂₅NO₆.................................M.W. 399.44

Colchicine consists of pale yellow scales or powder; it darkens on exposure to light. Colchicine is soluble in water, freely soluble in alcohol and in chloroform, and slightly soluble in ether. Each tablet for oral administration contains 500 mg of probenecid and 0.5 mg of colchicine.

Each tablet also contains the following inactive ingredients: colloidal silicon dioxide, magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate and sodium starch glycolate.

What are the possible side effects of colchicine and probenecid ()?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using colchicine and probenecid and call your doctor at once if you have any of these serious side effects:

painful urination, severe pain in your lower back or side;
easy bruising or bleeding, unusual weakness; or
severe diarrhea, nausea, vomiting, or stomach pain.

Continue using colchicine and probenecid and talk...

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What are the precautions when taking probenecid and colchicine (Probenecid and Colchicine)?

Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or to other calcium channel blockers (e.g., amlodipine, felodipine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart diseases (e.g., congestive heart failure, aortic stenosis), liver problems, esophagus/stomach/intestine problems (e.g., narrowing/stricture, motility disorders, or obstruction), kidney problems, a certain metabolic disorder (porphyria).

Before having surgery, tell your doctor or dentist that you are taking this medication.

This drug...

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Last reviewed on RxList: 9/29/2008
This monograph has been modified to include the generic and brand name in many instances.