Probenecid and Colchicine

Probenecid and Colchicine

OVERDOSE

No information provided.

CONTRAINDICATIONS

Hypersensitivity to this product or to probenecid or colchicine.

Probenecid and colchicines tablets are contraindicated in children under 2 years of age.

Not recommended in persons with known blood dyscrasias or uric acid kidney stones.

Therapy with probenecid and colchicine should not be started until an acute gouty attack has subsided.

Pregnancy

Probenecid crosses the placental barrier and appears in cord blood. Colchicine can arrest cell division in animals and plants. In certain species of animals under certain conditions, colchicines has produced teratogenic effects. The possibility of such effects in humans also has been reported. Because of the colchicine component, probenecid and colchicine is contraindicated in pregnant patients. The use of any drug in women of childbearing potential requires that the anticipated benefit be weighed against the possible hazards.

Last reviewed on RxList: 9/29/2008
This monograph has been modified to include the generic and brand name in many instances.

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