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In this Article

• What is colchicine and probenecid ?
• What are the possible side effects of colchicine and probenecid ?
• What is the most important information I should know about colchicine and probenecid ?
• What should I discuss with my health care provider before taking colchicine and probenecid ?
• How should I take colchicine and probenecid ?
• What happens if I miss a dose ?
• What happens if I overdose ?
• What should I avoid while taking colchicine and probenecid ?
• What other drugs will affect colchicine and probenecid ?
• Where can I get more information?

What happens if I miss a dose ?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose ?

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a colchicine and probenecid overdose may include blood in your urine, urinating less than usual, heartburn, severe diarrhea, nausea, vomiting, fever, severe muscle weakness, mood changes, trouble breathing, seizure (convulsions).

What should I avoid while taking colchicine and probenecid ?

Avoid drinking alcohol, which can raise uric acid levels in your blood and may also increase your risk of stomach problems caused by colchicine and probenecid.

What other drugs will affect colchicine and probenecid ?

Before taking colchicine and probenecid, tell your doctor if you are using any of the following drugs:

• amphotericin B (Fungizone);
• azathioprine (Imuran);
• cyclophosphamide (Cytoxan);
• flucytosine (Ancobon);
• ganciclovir (Cytovene);
• heparin;
• indomethacin (Indocin);
• interferon (Intron A, Roferon-A);
• ketoprofen (Orudis);
• mercaptopurine (Purinethol);
• methotrexate (Rheumatrex);
• nitrofurantoin (Macrodantin, Macrobid);
• phenylbutazone (Butazolidin);
• plicamycin (Mithracin);
• zidovudine (Retrovir);
• salicylates such as aspirin, Disalcid, Doan's Pills, Dolobid, Pepto-Bismol, Salflex, Tricosal, and others;
• medicines to treat tuberculosis or viral infections; or
• medicine to treat overactive thyroid.

If you are using any of these drugs, you may not be able to use colchicine and probenecid, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect colchicine and probenecid. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist has more information about colchicine and probenecid written for health professionals that you may read.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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