Probenecid and Colchicine
"An advisory committee to the US Food and Drug Administration (FDA) voted 10 to 4 to recommend lesinurad (Zurampic, AstraZeneca) 200 mg once daily for the treatment of gout-associated hyperuricemia, in combination with a xanthine oxidase "...
Probenecid and Colchicine
Probenecid and Colchicine Patient Information including If I Miss a Dose
In this Article
- What is colchicine and probenecid ?
- What are the possible side effects of colchicine and probenecid ?
- What is the most important information I should know about colchicine and probenecid ?
- What should I discuss with my health care provider before taking colchicine and probenecid ?
- How should I take colchicine and probenecid ?
- What happens if I miss a dose ?
- What happens if I overdose ?
- What should I avoid while taking colchicine and probenecid ?
- What other drugs will affect colchicine and probenecid ?
- Where can I get more information?
What happens if I miss a dose ?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
What happens if I overdose ?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include blood in your urine, urinating less than usual, heartburn, severe diarrhea, nausea, vomiting, fever, severe muscle weakness, mood changes, trouble breathing, seizure (convulsions).
What should I avoid while taking colchicine and probenecid ?
Avoid drinking alcohol, which can raise uric acid levels in your blood and may also increase your risk of stomach problems caused by colchicine and probenecid.
What other drugs will affect colchicine and probenecid ?
Before taking colchicine and probenecid, tell your doctor if you are using any of the following drugs:
- amphotericin B (Fungizone);
- azathioprine (Imuran);
- cyclophosphamide (Cytoxan);
- flucytosine (Ancobon);
- ganciclovir (Cytovene);
- indomethacin (Indocin);
- interferon (Intron A, Roferon-A);
- ketoprofen (Orudis);
- mercaptopurine (Purinethol);
- methotrexate (Rheumatrex);
- nitrofurantoin (Macrodantin, Macrobid);
- phenylbutazone (Butazolidin);
- plicamycin (Mithracin);
- zidovudine (Retrovir);
- salicylates such as aspirin, Disalcid, Doan's Pills, Dolobid, Pepto-Bismol, Salflex, Tricosal, and others;
- medicines to treat tuberculosis or viral infections; or
- medicine to treat overactive thyroid.
If you are using any of these drugs, you may not be able to use colchicine and probenecid, or you may need dosage adjustments or special tests during treatment.
There may be other drugs not listed that can affect colchicine and probenecid. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Where can I get more information?
Your pharmacist has more information about colchicine and probenecid written for health professionals that you may read.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2013 Cerner Multum, Inc. Version: 1.05. Revision date: 12/15/2010.
Your use of the content provided in this service indicates that you have read,understood and agree to the End-User License Agreement,which can be accessed by clicking on this link.
Additional Probenecid and Colchicine Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Find out what women really need.