Probenecid and Colchicine
"An advisory committee to the US Food and Drug Administration (FDA) voted 10 to 4 to recommend lesinurad (Zurampic, AstraZeneca) 200 mg once daily for the treatment of gout-associated hyperuricemia, in combination with a xanthine oxidase "...
Probenecid and Colchicine
Probenecid and Colchicine Patient Information including How Should I Take
In this Article
- What is colchicine and probenecid ?
- What are the possible side effects of colchicine and probenecid ?
- What is the most important information I should know about colchicine and probenecid ?
- What should I discuss with my health care provider before taking colchicine and probenecid ?
- How should I take colchicine and probenecid ?
- What happens if I miss a dose ?
- What happens if I overdose ?
- What should I avoid while taking colchicine and probenecid ?
- What other drugs will affect colchicine and probenecid ?
- Where can I get more information?
What should I discuss with my health care provider before taking colchicine and probenecid ?
This medication will not stop a gout attack that has already started. Your doctor may prescribe other medications to treat your gout. Keep taking colchicine and probenecid on a regular schedule, even if you take other gout medications.
Before using colchicine and probenecid, tell your doctor if you have:
- heart disease;
- kidney disease or a history of kidney stones;
- liver disease;
- a blood disease;
- stomach problems such as an ulcer or severe intestinal disorder;
- if you drink large amounts of alcohol; or
- if you are receiving a cancer treatment, including chemotherapy or radiation.
If you have any of these conditions, you may not be able to use colchicine and probenecid, or you may need a dosage adjustment or special tests during treatment.
Colchicine and probenecid may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
It is not known whether this medication passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using colchicine and probenecid.
Older adults may be more sensitive to the side effects of this medication.
How should I take colchicine and probenecid ?
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor.
Your doctor may occasionally change your dose to make sure you get the best results from this medication.
You may take this medicine with food or milk if it upsets your stomach. You may also use an antacid.
You may not notice the effects of this medicine right away. Your gout attacks should occur less often as you continue to take colchicine and probenecid. Taking the medicine for several months may cause the attacks to stop altogether. It is important to use the medication regularly to get the most benefit. Tell your doctor if your symptoms do not improve.
Drink several full glasses of water every day to prevent kidney stones. Follow your doctor's instructions about the type and amount of liquids you should drink each day.
To be sure this medication is helping your condition, your doctor will need to check your progress on a regular basis. Your kidney function may also need to be tested. It is important that you not miss any scheduled visits to your doctor.
Store colchicine and probenecid at room temperature away from moisture and heat.
Additional Probenecid and Colchicine Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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