Brand Names:

Generic Name: colchicine and probenecid (Pronunciation: KOL chi seen and pro BEN e sid)

• What is colchicine and probenecid ?
• What are the possible side effects of colchicine and probenecid ?
• What is the most important information I should know about colchicine and probenecid ?
• What should I discuss with my health care provider before taking colchicine and probenecid ?
• How should I take colchicine and probenecid ?
• What happens if I miss a dose ?
• What happens if I overdose ?
• What should I avoid while taking colchicine and probenecid ?
• What other drugs will affect colchicine and probenecid ?
• Where can I get more information?

What is colchicine and probenecid ?

Colchicine alters the way your body responds to uric acid crystals. Too much uric acid in the body is what leads to the symptoms of gout (swelling and pain).

Probenecid reduces the amount of uric acid in your body by causing it to be passed in your urine.

The colchicine and probenecid combination is used to prevent gout attacks. This medication will not cure gout and it will not stop a gout attack that has already started.

Colchicine and probenecid may also be used for purposes other than those listed in this medication guide.

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Colchicine-Probenecid-WAT

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What are the possible side effects of colchicine and probenecid ?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using colchicine and probenecid and call your doctor at once if you have any of these serious side effects:

• painful urination, severe pain in your lower back or side;
• easy bruising or bleeding, unusual weakness; or
• severe diarrhea, nausea, vomiting, or stomach pain.

Continue using colchicine and probenecid and talk with your doctor if you have any of these less serious side effects:

• mild nausea, vomiting, stomach pain, loss of appetite;
• headache;
• dizziness;
• hair loss; or
• warmth or tingly feeling.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about colchicine and probenecid ?

This medication will not stop a gout attack that has already started. Your doctor may prescribe other medications to treat your gout. Keep taking colchicine and probenecid on a regular schedule, even if you take other gout medications.

You may not notice the effects of this medicine right away. Your gout attacks should occur less often as you continue to take colchicine and probenecid. Taking the medicine for several months may cause the attacks to stop altogether. It is important to use the medication regularly to get the most benefit. Tell your doctor if your symptoms do not improve.

To be sure this medication is helping your condition, your doctor will need to check your progress on a regular basis. Your kidney function may also need to be tested. It is important that you not miss any scheduled visits to your doctor.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using colchicine and probenecid.