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Probenecid and Colchicine

Last reviewed on RxList: 12/25/2016
Probenecid and Colchicine Patient Information Including Side Effects

Brand Names:

Generic Name: colchicine and probenecid (Pronunciation: KOL chi seen and pro BEN e sid)

What is colchicine and probenecid ?

Colchicine alters the way your body responds to uric acid crystals. Too much uric acid in the body is what leads to the symptoms of gout (swelling and pain).

Probenecid reduces the amount of uric acid in your body by causing it to be passed in your urine.

The colchicine and probenecid combination is used to prevent gout attacks. This medication will not cure gout and it will not stop a gout attack that has already started.

Colchicine and probenecid may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of colchicine and probenecid ?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using colchicine and probenecid and call your doctor at once if you have any of these serious side effects:

  • painful urination, severe pain in your lower back or side;
  • easy bruising or bleeding, unusual weakness; or
  • severe diarrhea, nausea, vomiting, or stomach pain.

Continue using colchicine and probenecid and talk with your doctor if you have any of these less serious side effects:

  • mild nausea, vomiting, stomach pain, loss of appetite;
  • headache;
  • dizziness;
  • hair loss; or
  • warmth or tingly feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Probenecid and Colchicine (probenecid and colchicine) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about colchicine and probenecid ?

This medication will not stop a gout attack that has already started. Your doctor may prescribe other medications to treat your gout. Keep taking colchicine and probenecid on a regular schedule, even if you take other gout medications.

You may not notice the effects of this medicine right away. Your gout attacks should occur less often as you continue to take colchicine and probenecid. Taking the medicine for several months may cause the attacks to stop altogether. It is important to use the medication regularly to get the most benefit. Tell your doctor if your symptoms do not improve.

To be sure this medication is helping your condition, your doctor will need to check your progress on a regular basis. Your kidney function may also need to be tested. It is important that you not miss any scheduled visits to your doctor.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using colchicine and probenecid.

Probenecid and Colchicine Patient Information including How Should I Take

What should I discuss with my health care provider before taking colchicine and probenecid ?

This medication will not stop a gout attack that has already started. Your doctor may prescribe other medications to treat your gout. Keep taking colchicine and probenecid on a regular schedule, even if you take other gout medications.

Before using colchicine and probenecid, tell your doctor if you have:

  • heart disease;
  • kidney disease or a history of kidney stones;
  • liver disease;
  • a blood disease;
  • stomach problems such as an ulcer or severe intestinal disorder;
  • if you drink large amounts of alcohol; or
  • if you are receiving a cancer treatment, including chemotherapy or radiation.

If you have any of these conditions, you may not be able to use colchicine and probenecid, or you may need a dosage adjustment or special tests during treatment.

Colchicine and probenecid may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether this medication passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using colchicine and probenecid.

Older adults may be more sensitive to the side effects of this medication.

How should I take colchicine and probenecid ?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

You may take this medicine with food or milk if it upsets your stomach. You may also use an antacid.

You may not notice the effects of this medicine right away. Your gout attacks should occur less often as you continue to take colchicine and probenecid. Taking the medicine for several months may cause the attacks to stop altogether. It is important to use the medication regularly to get the most benefit. Tell your doctor if your symptoms do not improve.

Drink several full glasses of water every day to prevent kidney stones. Follow your doctor's instructions about the type and amount of liquids you should drink each day.

To be sure this medication is helping your condition, your doctor will need to check your progress on a regular basis. Your kidney function may also need to be tested. It is important that you not miss any scheduled visits to your doctor.

Store colchicine and probenecid at room temperature away from moisture and heat.

Probenecid and Colchicine Patient Information including If I Miss a Dose

What happens if I miss a dose ?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose ?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include blood in your urine, urinating less than usual, heartburn, severe diarrhea, nausea, vomiting, fever, severe muscle weakness, mood changes, trouble breathing, seizure (convulsions).

What should I avoid while taking colchicine and probenecid ?

Avoid drinking alcohol, which can raise uric acid levels in your blood and may also increase your risk of stomach problems caused by colchicine and probenecid.

What other drugs will affect colchicine and probenecid ?

Before taking colchicine and probenecid, tell your doctor if you are using any of the following drugs:

  • amphotericin B (Fungizone);
  • azathioprine (Imuran);
  • cyclophosphamide (Cytoxan);
  • flucytosine (Ancobon);
  • ganciclovir (Cytovene);
  • heparin;
  • indomethacin (Indocin);
  • interferon (Intron A, Roferon-A);
  • ketoprofen (Orudis);
  • mercaptopurine (Purinethol);
  • methotrexate (Rheumatrex);
  • nitrofurantoin (Macrodantin, Macrobid);
  • phenylbutazone (Butazolidin);
  • plicamycin (Mithracin);
  • zidovudine (Retrovir);
  • salicylates such as aspirin, Disalcid, Doan's Pills, Dolobid, Pepto-Bismol, Salflex, Tricosal, and others;
  • medicines to treat tuberculosis or viral infections; or
  • medicine to treat overactive thyroid.

If you are using any of these drugs, you may not be able to use colchicine and probenecid, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect colchicine and probenecid. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist has more information about colchicine and probenecid written for health professionals that you may read.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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