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(3% Amino Acid and 3% Glycerin) Injection with Electrolytes
Protect from light until use.
ProcalAmine (3% Amino Acid and 3% Glycerin Injection with Electrolytes) is a sterile, nonpyrogenic, moderately hypertonic intravenous injection containing crystalline amino acids, a nonprotein energy substrate and maintenance electrolytes. A 1000 mL unit provides a total of 29 g of protein equivalent (4.6 g N) and 130 nonprotein calories.
All amino acids designated USP are the "L"-isomer with the exception of Glycine USP which does not have an isomer.
Each 100 mL contains:
Nonprotein energy source:
Glycerin USP (glycerol) 3.0 g
Essential amino acids
Isoleucine USP 0.21 g
Leucine USP 0.27 g
Lysine 0.22 g (added as Lysine Acetate USP 0.31 g)
Methionine USP 0.16 g
Phenylalanine USP 0.17 g
Threonine USP 0.12 g
Tryptophan USP 0.046 g
Valine USP 0.20 g
Nonessential amino acids
Alanine USP 0.21 g
Glycine USP 0.42 g
Arginine USP 0.29 g
Histidine USP 0.085 g
Proline USP 0.34 g
Serine USP 0.18 g
Cysteine < 0.014 g (as Cysteine HCl•H2O USP < 0.020 g)
Sodium Acetate•3H2O USP 0.20 g
Magnesium Acetate•4H2O 0.054 g
Calcium Acetate•H2O 0.026 g
Sodium Chloride USP 0.12 g
Potassium Chloride USP 0.15g
Phosphoric Acid NF 0.041 g
Potassium Metabisulfite NF (as an antioxidant) < 0.05 g
Water for Injection USP qs
pH adjusted with Glacial Acetic Acid USP
pH: 6.8 (6.5-7.0), Calculated Osmolarity: 735 mOsmol/liter
Concentration of Electrolytes (mEq/liter): Sodium 35; Potassium 24.5; Calcium 3 Magnesium 5; Chloride 41; Phosphate (HPO=4) 7*; Acetate 47**
*3.5 mmole/liter; 10.9 mg% P
**Acetate is provided as inorganic acetate salts (23 mEq/liter), acetic acid (9 mEq/liter), and lysine acetate (15 mEq/liter). It is thought that acetate from lysine acetate and acetic acid, under the conditions of parenteral nutrition does not impact net acid/base balance when renal and respiratory functions are normal. Clinical experience seems to support this thinking, although confirmatory experimental evidence is not available.
Last reviewed on RxList: 12/18/2008
This monograph has been modified to include the generic and brand name in many instances.
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