"Repeated administration of ketamine may help sustain the antidepressant effect in patients with treatment-resistant depression beyond the initial dose, a new study shows.
Ketamine, an injectable anesthetic, has demonstrated a rapid an"...
(Generic versions may still be available.)
Positive ANA Titer: The prolonged administration of procainamide often leads in the development of a positive anti-nuclear antibody (ANA) test, with or without symptoms of a lupus erythematosus-like syndrome. If a positive ANA titer develops, the benefits versus risks of continued procainamide therapy should be assessed.
Procainamide hydrochloride, a Group 1A cardiac antiarrhythmic drug, is p-amino-N-[2-(diethylamino) ethyl]-benzamide monohydrochloride, molecular weight 271.79.
Procainamide Hydrochloride Extended-release Tablets meet USP Drug Release Dissolution Test 5
Procainamide Hydrochloride differs from procaine which is the p-aminobenzoyl ester of 2-(diethylamino)-ethenol. Procainamide as the free base has a pKa of 9.23; the monohydrochloride is very soluble in water. Procainamide Hydrochloride Extended-release Tablets, USP is available for oral administration as pink, scored, film-coated tablets containing 500 mg Procainamide hydrochloride, as light orange to tan, scored, film-coated tablets containing 750 mg procainamide hydrochloride, and as red scored film-coated tablets containing 1000 mg procainamide hydrochloride.
All strengths of Procainamide Hydrochloride contain calcium silicate, carnauba wax, NF; diethyl phthalate, NF; dimethyl Polysiloxane fluid; ethylcellulose, NF; hydroxypropyl methylcellulose 2910, USP; magnesium stearate NF; and vanillin, NF. The individual strengths contain additional ingredients as follows:
500 mg: D&C Red No. 30, aluminum lake; hydroxypropyl methylcellulose, USP; Polyethylene glycol, NF; polysorbate 80, NF; and titanium dioxide, USP.
750 mg: D&C Yellow No. 10, aluminum lake; FD&C Yellow. No 6, aluminum lake: hydroxypropyl methylcellulose, USP; polyethylene glycol. NF; polysorbate 80, NF; and titanium dioxide, USP.
1000 mg: FD&C Red No. 40, aluminum lake; polyethylene glycol, NF; Polysorbate 80, NF; and titanium dioxide, USP.
Procainamide Hydrochloride Extended-release Tablets contain a tablet matrix, designed for the controlled release of the drug through the gastrointestinal tract. The extended wax tablet Matrix, which is not absorbed, may be detected in the stool.
What are the possible side effects of procainamide injection (Pronestyl)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers at once if you have a serious side effect such as:
- a new or a worsening irregular heartbeat pattern;
- chest pain, wheezing, trouble breathing;
- feeling like you might pass out;
- signs of infection such as fever, chills, sore throat, flu symptoms, pale skin, easy bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, nausea and vomiting, sores in...
Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.
Additional Procan Sr Information
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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