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Procan Sr

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Procan Sr

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Procan Sr Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Procan SR (procainamide) is an antiarrhythmic drug used to help keep the heart beating normally in people with certain heart rhythm disorders of the ventricles (the lower chambers of the heart that allow blood to flow out of the heart). The brand name of this medication is discontinued, but generic versions may be available. Common side effects include dizziness or tired feeling, flushing (warmth, redness, or tingly feeling), itching, or rash.

An initial total daily oral dose of up to 50 mg/kg of body weight of Procan SR may be used, given in divided doses, every six hours, to maintain therapeutic blood levels. Procan SR may interact with cimetidine, digoxin, glycopyrrolate, mepenzolate, atropine, belladonna, benztropine, dimenhydrinate, methscopolamine, scopolamine, bronchodilators, irritable bowel syndrome medications, bladder or urinary medications, or heart rhythm medications. Tell your doctor all medications and supplements you use. It is unknown if Procan SR will harm a fetus. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. This drug can pass into breast milk and may harm a nursing baby. Do not breastfeed while using Procan SR.

Our Procan SR (procainamide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Procan Sr in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have a serious side effect such as:

  • a new or a worsening irregular heartbeat pattern;
  • chest pain, wheezing, trouble breathing;
  • feeling like you might pass out;
  • signs of infection such as fever, chills, sore throat, flu symptoms, pale skin, easy bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, nausea and vomiting, sores in your mouth and throat, unusual weakness;
  • depressed mood, hallucinations, severe dizziness;
  • upper stomach pain, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • joint pain or swelling with fever, swollen glands, muscle pain or weakness, unusual thoughts or behavior, patchy skin color, red spots.

Less serious side effects may include:

  • mild dizziness or tired feeling;
  • flushing (warmth, redness, or tingly feeling); or
  • mild itching or rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Procan Sr (Procainamide) »

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Procan Sr FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

Cardiovascular System: Hypotension following oral PA administration is rare. Hypotension and serious disturbances of cardiorhythm such as ventricular asystole or fibrillation are more common after intravenous administration (see OVERDOSAGE, WARNINGS). Second degree heart block has been reported in 2 of almost 500 patients taking PA orally.

Multisystem Effects: A lupus erythematosus-like syndrome of arthralgia, pleural or abdominal pain, and sometimes arthritis, pleural effusion, pericarditis, fever, chills, myalgia, and possibly related hematologic or skin lesions (see Below) is fairly common after prolonged PA administration, perhaps more often in patients who are slow acetylators (see

DESCRIPTION

: Boxed Warning and PRECAUTIONS). While some series have reported less than 1 in 500, others have reported the syndrome in up to 30 percent of patients on long-term oral PA therapy. If discontinuation of PA does not reverse the lupoid symptoms, corticosteroid treatment may be effective.

Hematologic System: Neutropenia, thrombocytopenia, or hemolytic anemia may rarely be encountered. Agranulocytosis has occurred after repeated use of PA, and deaths have been reported. (see WARNINGS and

DESCRIPTION

: Boxed Warning).

Skin: Angioneurotic edema, urticaria pruritus, flushing, and maculopapular rash have also occurred occasionally.

Gastrointestinal System: Anorexia, nausea, vomiting, abdominal pain, bitter taste, or diarrhea may occur in 3 to 4 percent of patients taking oral procainamide. Hepatomegaly with increased serum aminotransferase activity have been reported after a single oral dose.

Nervous System: Dizziness or giddiness, weakness, mental depression, and psychosis with hallucinations have been reported occasionally.

Read the entire FDA prescribing information for Procan Sr (Procainamide) »

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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