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The expected manifestations of PROCRIT® (epoetin alfa) overdosage include signs and symptoms associated with an excessive and/or rapid increase in hemoglobin concentration, including any of the cardiovascular events described in WARNINGS and listed in ADVERSE REACTIONS. Patients receiving an overdosage of PROCRIT® (epoetin alfa) should be monitored closely for cardiovascular events and hematologic abnormalities. Polycythemia should be managed acutely with phlebotomy, as clinically indicated. Following resolution of the effects due to PROCRIT® (epoetin alfa) overdosage, reintroduction of PROCRIT® (epoetin alfa) therapy should be accompanied by close monitoring for evidence of rapid increases in hemoglobin concentration ( > 1 gm/dL per 14 days). In patients with an excessive hematopoietic response, reduce the PROCRIT® (epoetin alfa) dose in accordance with the recommendations described in DOSAGE AND ADMINISTRATION.


PROCRIT® (epoetin alfa) is contraindicated in patients with:

  1. Uncontrolled hypertension.
  2. Known hypersensitivity to mammalian cell-derived products.
  3. Known hypersensitivity to Albumin (Human).
This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 6/20/2012


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