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home > drugs a-z list > procrit (epoetin alfa) drug center > procrit (epoetin alfa) drug - overdosage and contraindications
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Procrit
What is anemia?
Anemia is a medical condition in which the red blood cell count or hemoglobin is less than normal. The normal level of hemoglobin is generally different in males and females. For men, anemia is typically defined as hemoglobin level of less than 13.5 gram/100 ml and in women as hemoglobin of less than 12.0 gram/100 ml. These definitions may vary slightly depending on the source and the laboratory reference used.
What causes anemia?
Any process that can disrupt the normal life span of a red blood cell may cause anemia. Normal life span of a red blood cell is typically around 120 days. Red blood cells are made in the bone marrow.
Anemia is caused essentially through two basic pathways. Anemia is caused by either:
- a decrease in production of red blood cells or hemoglobin, or
- an increase in loss or destruction of red blood cells.
A more common classification of anemia (low hemo...
Procrit
OVERDOSE
The expected manifestations of PROCRIT® (epoetin alfa) overdosage include signs and symptoms associated with an excessive and/or rapid increase in hemoglobin concentration, including any of the cardiovascular events described in WARNINGS and listed in ADVERSE REACTIONS. Patients receiving an overdosage of PROCRIT® (epoetin alfa) should be monitored closely for cardiovascular events and hematologic abnormalities. Polycythemia should be managed acutely with phlebotomy, as clinically indicated. Following resolution of the effects due to PROCRIT® (epoetin alfa) overdosage, reintroduction of PROCRIT® (epoetin alfa) therapy should be accompanied by close monitoring for evidence of rapid increases in hemoglobin concentration ( > 1 gm/dL per 14 days). In patients with an excessive hematopoietic response, reduce the PROCRIT® (epoetin alfa) dose in accordance with the recommendations described in DOSAGE AND ADMINISTRATION.
CONTRAINDICATIONS
PROCRIT® (epoetin alfa) is contraindicated in patients with:
- Uncontrolled hypertension.
- Known hypersensitivity to mammalian cell-derived products.
- Known hypersensitivity to Albumin (Human).
Last reviewed on RxList: 2/26/2010
This monograph has been modified to include the generic and brand name in many instances.
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