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Progesterone Injection

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Progesterone Injection

INDICATIONS

This drug is indicated in amenorrhea and abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as submucous fibroids or uterine cancer.

DOSAGE AND ADMINISTRATION

Progesterone is administered by intramuscular injection. It differs from other commonly used steroids in that it is irritating at the place of injection.

Amenorrhea: Five to 10 mg are given for six to eight consecutive days. If there has been sufficient ovarian activity to produce a proliferative endometrium, one can expect withdrawal bleeding forty-eight to seventy-two hours after the last injection. This may be followed by spontaneous normal cycles.

Functional Uterine Bleeding: Five to 10 mg are given daily for six doses. Bleeding may be expected to cease within six days. When estrogen is given as well, the administration of progesterone is begun after two weeks of estrogen therapy. If menstrual flow begins during the course of injections of progesterone, they are discontinued.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever the solution and container permit.

HOW SUPPLIED

Progesterone Injection USP, 50 mg/mL is available in 10 mL multiple dose vials, individually boxed.

(NDC 0591-3128-79)

Store at controlled room temperature 15-30°C (59-86°F).

Watson Laboratories, Inc. Corona, CA 92880 USA. Revised: January 2007. FDA Rev date: 1/9/2007

Last reviewed on RxList: 2/20/2008
This monograph has been modified to include the generic and brand name in many instances.

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