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Progesterone Injection

Last reviewed on RxList: 10/18/2016
Progesterone Injection Side Effects Center

Last reviewed on RxList 10/25/2016

Progesterone injection is a type of female hormone given to replace the hormone progestin when the body is not making enough of it. In women who are not pregnant and have not gone through menopause, progesterone is used to restore normal menstrual periods that have stopped for several months (amenorrhea). Progesterone is also used to treat abnormal bleeding from the uterus that is due to low hormone levels and not other causes (e.g., fibroids, cancer of the uterus). Progesterone injection is available in generic form. Common side effects of progesterone injection include:

  • pain and swelling at injection site,
  • breast tenderness,
  • headache,
  • weight gain or loss,
  • acne,
  • nausea,
  • increased body or facial hair,
  • loss of scalp hair,
  • drowsiness, or
  • dizziness.

Tell your doctor right away if you have serious side effects from progesterone injection including:

To treat amenorrhea, administer five to 10 mg for six to eight consecutive days. For functional uterine bleeding, administer five to 10 mg daily for six doses. If menstrual flow begins during the course of injections of progesterone, they are discontinued. Progesterone injection may interact with azole antifungals, rifamycins, St. John's wort, or anti-seizure medicines. Tell your doctor all medications and supplements you use. Progesterone injection is not recommended for use during pregnancy because it may harm a fetus, especially during the first 4 months of pregnancy. If you become pregnant or think you may be pregnant, tell your doctor. This drug passes into breast milk. Consult your doctor before breastfeeding.

Our progesterone injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Progesterone Injection Consumer Information
SIDE EFFECTS: Pain/swelling at injection site, breast tenderness, headache, weight gain/loss, acne, nausea, increased body/facial hair, loss of scalp hair, drowsiness, or dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: unusual vaginal bleeding/discharge (e.g., breakthrough bleeding, spotting), stopped menstrual periods (amenorrhea), breast lumps, swelling of the ankles/feet, mental/mood changes (e.g., depression, nervousness), dark patches on the skin/face, frequent/painful urination, dark urine, yellowing eyes/skin, stomach/abdominal pain, persistent nausea/vomiting.

This drug may rarely cause blood clots. Get medical help right away if any of these rare but very serious side effects occur: chest/jaw/left arm pain, weakness on one side of the body, slurred speech, vision changes (e.g., blurred/double vision, loss of vision), confusion, pain/redness/swelling of arms or legs, trouble breathing, sudden severe headache, fainting.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the entire patient information overview for Progesterone Injection (Progesterone Injection)

Progesterone Injection Professional Information

SIDE EFFECTS

Breakthrough bleeding; spotting; change in menstrual flow; amenorrhea; edema; change in weight (increase or decrease); changes in cervical erosion and cervical secretions; cholestatic jaundice; breast tenderness and galactorrhea; pain, irritation, and/or redness at the injection area; skin sensitivity reactions consisting of urticaria, pruritus, edema and generalized rash; acne, alopecia and hirsutism; rash (allergic) with and without pruritus; anaphylactoid reactions; mental depression; pyrexia; insomnia; nausea; and somnolence.

A statistically significant association has been demonstrated between use of estrogen- progestin combination drugs and pulmonary embolism and cerebral thrombosis and embolism. For this reason patients on progestin therapy should be carefully observed. There is also evidence suggestive of an association with neuro-ocular lesions, e.g., retinal thrombosis and optic neuritis.

The following adverse reactions have been observed in patients receiving estrogen- progestin combination drugs: Rise in blood pressure in susceptible individual, premenstrual syndrome, changes in libido, changes in appetite, cystitis-like syndrome, headache, nervousness, fatigue, backache, hirsutism, loss of scalp hair, erythema multiforme, erythema nodosum, hemorrhagic eruption, itching, and dizziness.

The following laboratory results may be altered by the use of estrogen-progestin combination drugs: increased sulfobromophthalein retention and other hepatic function tests; coagulation tests: increase in prothrombin factors VII, VIII, IX, and X; metyrapone test; pregnanediol determinations; thyroid function: increase in PBI, and butanol extractable protein bound iodine and decrease in T3 uptake values.

Read the entire FDA prescribing information for Progesterone Injection (Progesterone Injection)

Related Resources for Progesterone Injection

Read the Progesterone Injection User Reviews »

© Progesterone Injection Patient Information is supplied by Cerner Multum, Inc. and Progesterone Injection Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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