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Proglycem Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Proglycem (oral diazoxide) is a non-diuretic benzothiadiazine derivative that works by preventing insulin release from the pancreas, helping to return the blood sugar to normal levels used to treat low blood sugar (hypoglycemia) related to certain cancers that affect the pancreas and cause it to release too much insulin. Common side effects of Proglycem include nausea, vomiting, loss of appetite, stomach pain or upset, diarrhea, changes in sense of taste, temporary increase in growth of body hair (especially in women and children), headache, dizziness, anxiety, weakness, or itching or skin rash.
The usual daily dosage of Proglycem for adults and children is 3 to 8 mg/kg, divided into two or three equal doses every 8 or 12 hours. The usual daily dosage for infants and newborns is 8 to 15 mg/kg divided into two or three equal doses every 8 to 12 hours. Proglycem may interact with diuretics (water pills), chlorpromazine, phenytoin, blood thinners, or drugs to treat high blood pressure or a prostate disorder. Tell your doctor all medications and supplements you use. During pregnancy, Proglycem should be used only when prescribed. If you become pregnant, or think you may be pregnant, tell your doctor. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.
Our Proglycem (oral diazoxide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Proglycem in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- shortness of breath, swelling in your hands or feet;
- rapid pulse;
- fast or pounding heartbeats;
- chest pain;
- blurred vision, eye pain, or seeing halos around lights;
- easy bruising or bleeding, unusual weakness;
- fever, chills, body aches, flu symptoms;
- urinating less than usual; or
- feeling like you might pass out.
Less serious side effects may include:
- temporary increase in growth of body hair (especially in women and children;
- nausea, vomiting, stomach pain, loss of appetite;
- decreased sense of taste;
- headache, dizziness, anxiety;
- weakness; or
- mild itching or skin rash.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Proglycem (Diazoxide Capsules)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Proglycem Overview - Patient Information: Side Effects
Abnormal growth of body hair, especially on the forehead/back/arms/legs, may occur. This is usually not permanent and will go away when the drug is stopped.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
This medication can cause sodium and water retention which can cause serious heart problems. Tell your doctor immediately if any of these serious side effects occur: swelling of arms/legs/hands/feet, unexplained weight gain, shortness of breath, unusual tiredness.
This medication may cause your blood sugar to become too high. Checking your blood sugar and urine for sugar/ketones regularly and telling your doctor the results will help prevent this side effect. High blood sugar can be very serious and worsen quickly. Tell your doctor immediately if any of these signs of very high blood sugar occur: need to urinate more often, unusual thirst, fruity breath odor, dizziness, unusual weight loss, deep/rapid breathing, extreme drowsiness/confusion, weakness.
Tell your doctor immediately if any of these unlikely but serious side effects occur: easy bruising/bleeding, fainting, fast/pounding heartbeat, face/muscle twitching, toe/joint pain, unusual restlessness, muscle cramps/stiffness, shaking (tremor).
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Proglycem (Diazoxide Capsules)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Proglycem FDA Prescribing Information: Side Effects
Frequent and Serious
Sodium and fluid retention is most common in young infants and in adults and may precipitate congestive heart failure in patients with compromised cardiac reserve. It usually responds to diuretic therapy (See DRUG INTERACTIONS).
Infrequent but Serious
Diabetic ketoacidosis and hyperosmolar nonketotic coma may develop very rapidly. Conventional therapy with insulin and restoration of fluid and electrolyte balance is usually effective if instituted promptly. Prolonged surveillance is essential in view of the long half-life of PROGLYCEM® (See OVERDOSAGE).
Other Frequent Adverse Reactions
Thrombocytopenia with or without purpura may require discontinuation of the drug. Neutropenia is transient, is not associated with increased susceptibility to infection, and ordinarily does not require discontinuation of the drug. Skin rash, headache, weakness, and malaise may also occur.
Other Adverse Reactions Which Have Been Observed Are
Cardiovascular: hypotension occurs occasionally, which may be augmented by thiazide diuretics given concurrently. A few cases of transient hypertension, for which no explanation is apparent, have been noted. Chest pain has been reported rarely. Pulmonary hypertension has been reported in neonates and young infants (see WARNINGS).
Hepato-renal: increased AST, alkaline phosphatase; azotemia, decreased creatinine clearance, reversible nephrotic syndrome, decreased urinary output, hematuria, albuminuria. Neurologic: anxiety, dizziness, insomnia, polyneuritis, paresthesia, pruritus, extrapyramidal signs.
Ophthalmologic: transient cataracts, subconjunctival hemorrhage, ring scotoma, blurred vision, diplopia, lacrimation. Skeletal, integumentary; monilial dermatitis, herpes, advance in bone age; loss of scalp hair. Systemic: fever, lymphadenopathy. Other; gout acute pancreatitis/pancreatic necrosis, galactorrhea, enlargement of lump in breast.
Read the entire FDA prescribing information for Proglycem (Diazoxide Capsules)
Additional Proglycem Information
Proglycem - User Reviews
Proglycem User Reviews
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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