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Prograf Patient Information including If I Miss a Dose
In this Article
- What is tacrolimus (Prograf)?
- What are the possible side effects of tacrolimus (Prograf)?
- What is the most important information I should know about tacrolimus (Prograf)?
- What should I discuss with my healthcare provider before taking tacrolimus (Prograf)?
- How should I take tacrolimus (Prograf)?
- What happens if I miss a dose (Prograf)?
- What happens if I overdose (Prograf)?
- What should I avoid while taking tacrolimus (Prograf)?
- What other drugs will affect tacrolimus (Prograf)?
- Where can I get more information?
What happens if I miss a dose (Prograf)?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose (Prograf)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking tacrolimus (Prograf)?
Grapefruit and grapefruit juice may interact with tacrolimus and lead to potentially dangerous effects. Do not use grapefruit products while you are taking tacrolimus.
Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.
Avoid exposure to sunlight or tanning beds. Tacrolimus can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Do not receive a "live" vaccine while using tacrolimus. The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), Bacillus Calmette-Guérin (BCG), oral polio, rotavirus, smallpox, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.
What other drugs will affect tacrolimus (Prograf)?
Tacrolimus can harm your kidneys. This effect is increased when you also use other medicines harmful to the kidneys, such as: chemotherapy, antiviral medication, pain or arthritis medicine, injected antibiotics, or medicines to treat a bowel disorder or prevent organ transplant rejection. You may need dose adjustments or special tests if you have recently used any of these medications.
Many drugs can interact with tacrolimus. Below is just a partial list. Tell your doctor about all other medicines you use, especially:
- other medicines to prevent rejection of a transplanted organ;
- St. John's wort;
- antacids such as Amphojel, Maalox, Mylanta, Rolaids, Rulox, and others;
- an antibiotic such as azithromycin (Zithromax, Zmax, Z-Pack), clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), levofloxacin (Levaquin), rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), and others;
- an antidepressant such as desipramine (Norpramin) or nefazodone;
- antifungal medication such as caspofungin (Cancidas), clotrimazole (Mycelex Troche), itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), or voriconazole (Vfend);
- a barbiturate such as phenobarbital (Solfoton);
- birth control pills or hormone replacement;
- heart or blood pressure medication such as amiodarone (Cordarone, Pacerone), amlodipine (Norvasc, Caduet, Exforge, Lotrel, Tekamlo, Tribenzor, Twynsta, Amturnide), diltiazem (Cardizem, Cartia, Dilacor, Diltia, Diltzac, Taztia, Tiazac), dronedarone (Multaq), nifedipine (Nifedical, Procardia), quinidine (Quin-G), verapamil (Calan, Covera, Isoptin, Verelan, Tarka), and others;
- HIV/AIDS medication such as atazanavir (Reyataz), efavirenz (Sustiva, Atripla), fosamprenavir (Lexiva), nelfinavir (Viracept), ritonavir (Norvir, Kaletra), and others;
- the hepatitis C medications boceprevir (Victrelis) or telaprevir (Incivek);
- seizure medication such as carbamazepine (Carbatrol, Equetro, Tegretol), phenytoin (Dilantin), and others;
- steroid medicine such as dexamethasone (Cortastat, Dexasone, Solurex, DexPak) or methylprednisolone (Medrol); or
- stomach acid reducers such as cimetidine (Tagamet), lansoprazole (Prevacid), or omeprazole (Prilosec, Zegerid).
This list is not complete and there are many other drugs that can interact with tacrolimus. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.
Where can I get more information?
Your pharmacist can provide more information about tacrolimus.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2013 Cerner Multum, Inc. Version: 6.01. Revision date: 9/13/2012.
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Additional Prograf Information
- Prograf Drug Interactions Center: tacrolimus oral
- Prograf Side Effects Center
- Prograf Overview including Precautions
- Prograf FDA Approved Prescribing Information including Dosage
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