Promacta (Eltrombopag Tablets) Patient Information: Missed a Dose and What Should I Avoid at RxList

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May 27, 2012

Promacta

Thrombocytopenia (Low Platelet Count) »

What is thrombocytopenia?

Thrombocytopenia is a lower than normal number of platelets in the blood.

Platelets are one of the components of the blood along with white and red blood cells. Platelets play an important role in clotting and bleeding. Platelets are made in the bone marrow similar to other cells in the blood such as, white blood cells and red blood cells. Platelets originate from megakaryocytes which are large cells found in the bone marrow. The fragments of these megakaryocytes are platelets that are released into the blood stream. The circulating platelets make up about two third of the platelets that are released from the bone marrow. The other one third is typically stored (sequestered) in the spleen.

Platelets, in general, have a brief 7 to 10 days life in the blood, after which they are removed from the blood circulation. The number of platelets in the blood is referred to as the platelet count and is normally betw...

Read the Thrombocytopenia (Low Platelet Count) article »

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Promacta

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Promacta Patient Information including If I Miss a Dose

What happens if I miss a dose (Promacta)?

Call your doctor for instructions if you miss an appointment for your eltrombopag injection.

What happens if I overdose (Promacta)?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose can cause slow heart rate, skin rash, or signs of a blood clot such as sudden numbness or weakness, sudden headache or confusion, problems with vision or speech, loss of balance, chest pain, sudden cough, and pain or swelling in one or both legs.

What should I avoid while taking eltrombopag (Promacta)?

Avoid taking other medications, including antacids or vitamin and mineral supplements, within 4 hours before or after you take eltrombopag.

What other drugs will affect eltrombopag (Promacta)?

The following drugs can interact with eltrombopag. Tell your doctor if you are using any of these:

acyclovir (Zovirax);
antacids;
atazanavir (Reyataz);
birth control pills;
cimetidine (Tagamet);
famotidine (Pepcid);
fluvoxamine (Luvox);
gemfibrozil (Lopid);
methotrexate (Rheumatrex, Trexall);
rifampin (Rifadin, Rifater, Rifamate);
ticlopidine (Ticlid);
trimethoprim (Proloprim, Bactrim, Septra);
zileuton (Zyflo);
an antibiotic such as ciprofloxacin (Cipro), ofloxacin (Floxin), levofloxacin (Levaquin), lomefloxacin (Maxaquin), and others;
cholesterol-lowering medicines such as atorvastatin (Lipitor), fluvastatin (Lescol), or rosuvastatin (Crestor);
diabetes medication you take by mouth, such as nateglinide (Starlix), pioglitazone (Actos), repaglinide (Prandin), rosiglitazone (Avandia); or
heart rhythm medication such as amiodarone (Cordarone, Pacerone), mexiletine (Mexitil), propafenone (Rythmol), verapamil (Calan, Covera, Isoptin).

This list is not complete and there may be other drugs that can interact with eltrombopag. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

Your doctor or pharmacist can provide more information about eltrombopag.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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