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Promethazine HCl and Dextromethorphan Hydrobromide Syrup

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Promethazine HCl and Dextromethorphan Hydrobromide Syrup

Promethazine HCl and Dextromethorphan Hydrobromide
(promethazine HCl and dextromethorphan hydrobromide (promethazine and dextromethorphan) ) Syrup

DRUG DESCRIPTION

Each teaspoon (5 mL) of Promethazine HCl and Dextromethorphan Hydrobromide (promethazine and dextromethorphan) Syrup contains 6.25 mg promethazine HCl and 15 mg dextromethorphan hydrobromide in a flavored syrup base with a pH between 4.7 and 5.2. Alcohol 7%. The inactive ingredients present are artificial and natural flavors, citric acid, D&C Yellow 10, FD&C Yellow 6, glycerin, saccharin sodium, sodium benzoate, sodium citrate, sodium propionate, water, and other ingredients.

Promethazine HCl is a racemic compound; the empirical formula is C17H20N2S•HCl and its molecular weight is 320.88.

Promethazine HCl, a phenothiazine derivative, is chemically designated as 10H-Phenothiazine-10- ethanamine, N,N, α-trimethyl-, monohydrochloride, (±)- with the following structural formula:

Promethazine HCl structural formula illustration

Promethazine HCl occurs as a white to faint yellow, practically odorless, crystalline powder which slowly oxidizes and turns blue on prolonged exposure to air. It is freely soluble in water and soluble in alcohol.

Dextromethorphan hydrobromide is a salt of the methyl ether of the dextrorotatory isomer of levorphanol, a narcotic analgesic. It is chemically designated as 3-methoxy-17-methyl-9α, 13α, 14α- morphinan hydrobromide monohydrate with the following structural formula:

Dextromethorphan hydrobromide structural formula illustration

Dextromethorphan hydrobromide monohydrate occurs as white crystals, is sparingly soluble in water, and is freely soluble in alcohol. The empirical formula is C18H25NO•HBr•H2O, and the molecular weight of the monohydrate is 370.33. Dextromethorphan HBr monohydrate is dextrorotatory with a specific rotation of +27.6 degrees in water (20 degrees C, sodium D-line).

What are the possible side effects of dextromethorphan and promethazine (Promethazine with Dextromethorphan, Promethazine with DM)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using dextromethorphan and promethazine and call your doctor at once if you have any of these serious side effects:

  • uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
  • tremors, twitching, or uncontrolled muscle movements in your face, arms, or legs.
  • severe dizziness, anxiety, restless feeling, or...

Read All Potential Side Effects and See Pictures of Promethazine HCl and Dextromethorphan Hydrobromide Syrup »

What are the precautions when taking promethazine and dextromethorphan (Promethazine HCl and Dextromethorphan Hydrobromide Syrup)?

See also Warning section.

Before taking this medication, tell your doctor or pharmacist if you are allergic to promethazine or to dextromethorphan; or to any other phenothiazines (such as prochlorperazine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (such as asthma, emphysema, sleep apnea), heart problems (such as slow/irregular heartbeat, chest pain), liver problems, difficulty urinating (such as due to an enlarged prostate), stomach/bowel problems (such as blockage, ulcer), high blood pressure, diabetes, a certain eye...

Read All Potential Precautions of Promethazine HCl and Dextromethorphan Hydrobromide Syrup »

Last reviewed on RxList: 5/15/2008
This monograph has been modified to include the generic and brand name in many instances.

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Promethazine HCl and Dextromethorphan Hydrobromide Syrup - User Reviews

Promethazine HCl and Dextromethorphan Hydrobromide Syrup User Reviews

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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