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Promethazine HCl and Dextromethorphan Hydrobromide Syrup

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Promethazine HCl and Dextromethorphan Hydrobromide Syrup

Promethazine HCl and Dextromethorphan Hydrobromide Syrup

Promethazine HCl and Dextromethorphan Hydrobromide Syrup Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Promethazine HCl and Dextromethorphan Hydrobromide Syrup is used to treat cough, itching, runny nose, sneezing, and itchy or watery eyes caused by colds or allergies. Promethazine is an antihistamine, and dextromethorphan is a cough suppressant. This medication is available in generic form. Common side effects include drowsiness, dizziness, blurred vision, nausea, or dry mouth.

The dose of Promethazine HCl and Dextromethorphan Hydrobromide Syrup for adults is one tsp every 4 to 6 hours. Children 6 years to 12 years, the dose is one-half to one tsp every 4 to 6 hours. Children 2 years to 6 years, the dose is one-quarter to one-half tsp every 4 to 6 hours. Promethazine and Dextromethorphan may interact with elecoxib, cinacalcet, darifenacin, imatinib, quinidine, ranolazine, ritonavir, sibutramine, terbinafine, medicines to treat high blood pressure, antidepressants, sedatives or anxiety medicines, barbiturates, atropine, belladonna, clidinium, dicyclomine, glycopyrrolate, hyoscyamine, methscopolamine, and scopolamine. Tell your doctor all medications you use. During pregnancy, Promethazine HCl and Dextromethorphan Hydrobromide should be used only if prescribed. It is unknown if this medication passes into breast milk. It may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

Our Promethazine HCl and Dextromethorphan Hydrobromide Syrup Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Promethazine HCl and Dextromethorphan Hydrobromide Syrup in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using dextromethorphan and promethazine and call your doctor at once if you have any of these serious side effects:

  • uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
  • tremors, twitching, or uncontrolled muscle movements in your face, arms, or legs.
  • severe dizziness, anxiety, restless feeling, or nervousness;
  • hallucinations (seeing or hearing things);
  • confusion, hallucinations; or
  • slow, shallow breathing, weak pulse;
  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • fever, muscle stiffness, confusion, fast or uneven heartbeat, sweating, fainting.

Keep taking dextromethorphan and promethazine and talk with your doctor if you have any of these less serious side effects:

  • dizziness, drowsiness, sleepiness, or confusion;
  • blurred vision, dry mouth;
  • ringing in your ears;
  • nausea or vomiting; or
  • increased sensitivity to sunlight.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Promethazine HCl and Dextromethorphan Hydrobromide Syrup (Promethazine and Dextromethorphan) »

What is Patient Information Overview?

A concise overview of the drug for the patient or caregiver from First DataBank.

Promethazine HCl and Dextromethorphan Hydrobromide Syrup Overview - Patient Information: Side Effects

SIDE EFFECTS: Drowsiness, dizziness, blurred vision, nausea, or dry mouth may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

To minimize dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

If you are very sleepy or have difficulty waking up after using this medication, stop taking this medication and talk to your doctor or pharmacist immediately. Your dosage may need to be lower.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: decreased coordination, difficulty urinating, shaking (tremor).

Stop taking this medication and seek immediate medical attention if any of these rare but serious side effects occur: fast/slow/irregular heartbeat, fainting, slow/shallow breathing, mental/mood changes (such as nervousness, excitement, irritability, confusion, hallucinations), abnormal/involuntary movements (such as fixed upward stare, neck twisting, tongue movements).

Promethazine may rarely cause a serious condition called neuroleptic malignant syndrome (NMS). Seek immediate medical attention if you develop the following: fever, muscle stiffness, severe confusion, sweating, seizures, fast/irregular heartbeat.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the entire patient information overview for Promethazine HCl and Dextromethorphan Hydrobromide Syrup (Promethazine and Dextromethorphan)»

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Promethazine HCl and Dextromethorphan Hydrobromide Syrup FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

Promethazine

Central Nervous System- Drowsiness is the most prominent CNS effect of this drug. Sedation, somnolence, blurred vision, dizziness; confusion, disorientation and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion; lassitude, tinnitus, incoordination, fatigue, euphoria, nervousness, diplopia, insomnia, tremors, convulsive seizures, excitation, catatonic-like states, hysteria. Hallucinations have also been reported.

Cardiovascular- Increased or decreased blood pressure, tachycardia, bradycardia, faintness.

Dermatologic - Dermatitis, photosensitivity, urticaria.

Hematologic- Leukopenia, thrombocytopenia, thrombocytopenic purpura, agranulocytosis.

Gastrointestinal - Dry mouth, nausea, vomiting, jaundice.

Respiratory - Asthma, nasal stuffiness, respiratory depression (potentially fatal) and apnea (potentially fatal) (see WARNINGS - Respiratory Depression.)

Other - Angioneurotic edema. Neuroleptic malignant syndrome (potentially fatal) has also been reported (see WARNINGS - Neuroleptic Malignant Syndrome.)

Paradoxical Reactions

Hyperexcitability and abnormal movements have been reported in patients following a single administration of Promethazine HCl and Dextromethorphan Hydrobromide Syrup. Consideration should be given to the discontinuation of promethazine HCl and to the use of other drugs if these reactions occur. Respiratory depression, nightmares, delirium, and agitated behavior have also been reported in some of these patients.

Dextromethorphan

Dextromethorphan hydrobromide occasionally causes slight drowsiness, dizziness, and gastrointestinal disturbances.

Drug Abuse And Dependence

According to the WHO Expert Committee on Drug Dependence, dextromethorphan could produce very slight psychic dependence but no physical dependence.

Read the entire FDA prescribing information for Promethazine HCl and Dextromethorphan Hydrobromide Syrup (Promethazine and Dextromethorphan) »

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Promethazine HCl and Dextromethorphan Hydrobromide Syrup - User Reviews

Promethazine HCl and Dextromethorphan Hydrobromide Syrup User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Promethazine HCl and Dextromethorphan Hydrobromide Syrup sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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