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Promethazine HCl Injection

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Promethazine HCl Injection

Promethazine Hydrochloride (promethazine hydrochloride injection)
Injection, USP

Promethazine HCl Injection

DRUG DESCRIPTION

Promethazine hydrochloride (promethazine hydrochloride injection) injection, is a sterile, pyrogen-free solution for deep intramuscular or intravenous administration. Promethazine hydrochloride (promethazine hydrochloride injection) (10H-phenothiazine-10-ethanamine, N, N, α-trimethyl-, monohydrochloride, (±)-) is a racemic compound and has the following structural formula:

Promethazine hydrochloride structural formula illustration

Each mL contains either 25 mg or 50 mg promethazine hydrochloride (promethazine hydrochloride injection) with 0.1 mg edetate disodium, 0.04 mg calcium chloride, 0.25 mg sodium metabisulfite, and 5 mg phenol in water for injection. The pH range is 4.0 to 5.5, buffered with acetic acid-sodium acetate, and it is sealed under nitrogen.

Promethazine hydrochloride (promethazine hydrochloride injection) injection is a clear, colorless solution. The product is light sensitive. It should be inspected before use and discarded if either color or particulate is observed.

What are the possible side effects of promethazine injection (Adgan, Anergan 50, Phenergan)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • twitching, or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
  • tremor (uncontrolled shaking), drooling, trouble swallowing, problems with balance or walking;
  • feeling restless, jittery, or agitated;
  • slow, shallow breathing, feeling like you might pass...

Read All Potential Side Effects and See Pictures of Promethazine HCl Injection »

Last reviewed on RxList: 6/21/2007
This monograph has been modified to include the generic and brand name in many instances.

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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