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Promethazine hydrochloride (promethazine hydrochloride injection) injection, is a sterile, pyrogen-free solution for deep intramuscular or intravenous administration. Promethazine hydrochloride (promethazine hydrochloride injection) (10H-phenothiazine-10-ethanamine, N, N, α-trimethyl-, monohydrochloride, (±)-) is a racemic compound and has the following structural formula:

Each mL contains either 25 mg or 50 mg promethazine hydrochloride (promethazine hydrochloride injection) with 0.1 mg edetate disodium, 0.04 mg calcium chloride, 0.25 mg sodium metabisulfite, and 5 mg phenol in water for injection. The pH range is 4.0 to 5.5, buffered with acetic acid-sodium acetate, and it is sealed under nitrogen.

Promethazine hydrochloride (promethazine hydrochloride injection) injection is a clear, colorless solution. The product is light sensitive. It should be inspected before use and discarded if either color or particulate is observed.

Last reviewed on RxList: 6/21/2007
This monograph has been modified to include the generic and brand name in many instances.