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Promethazine HCl Injection

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Promethazine HCl Injection

Promethazine HCl Injection Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Promethazine hydrochloride is used to treat or prevent nausea and vomiting caused by anesthesia or surgery, certain types of allergic reactions, pain caused by surgery or childbirth, and to sedate patients before surgery or medical procedures. Promethazine injection is usually given when a person cannot take the medication orally (by mouth). It is a phenothiazine. This medication is available in generic form. Common side effects include drowsiness, dizziness, tired feeling, ringing in the ears, problems with balance or coordination, blurred vision, feeling nervous or shaky, insomnia, skin rash or itching, dry mouth, or stuffy nose.

The average adult dose of promethazine hydrochloride is 25 mg. Promethazine hydrochloride may interact with cold or allergy medicine, sedatives, narcotics, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety, lithium, atropine, belladonna, benztropine, dimenhydrinate, methscopolamine, scopolamine, blood pressure medications, blood thinners, bronchodilators, bladder or urinary medications, MAO inhibitors, medicines to treat Parkinson's disease, restless leg syndrome, or pituitary gland tumor, or medicines to treat stomach ulcer or irritable bowel syndrome. Tell your doctor all medications and supplements you use. During pregnancy promethazine hydrochloride should be taken only if prescribed. It is unknown if it is harmful to a fetus. It is unknown if this drug passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

Our promethazine hydrochloride Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Promethazine HCl Injection in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • twitching, or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
  • tremor (uncontrolled shaking), drooling, trouble swallowing, problems with balance or walking;
  • feeling restless, jittery, or agitated;
  • slow, shallow breathing, feeling like you might pass out;
  • increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure);
  • pain, burning, severe irritation, muscle weakness, or skin changes where the injection was given;
  • confusion, hallucinations, hysteria, seizure (black-out or convulsions);
  • fast or slow heartbeats;
  • fever, chills, body aches, flu symptoms;
  • urinating less than usual or not at all;
  • easy bruising or bleeding, unusual weakness; or
  • jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • drowsiness, dizziness, tired feeling;
  • ringing in your ears;
  • problems with balance or coordination;
  • blurred vision;
  • feeling nervous or shaky;
  • sleep problems (insomnia);
  • skin rash or itching; or
  • dry mouth, stuffy nose.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Promethazine HCl Injection (Promethazine Hydrochloride Injection) »

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Promethazine HCl Injection FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

CNS Effects

Drowsiness is the most prominent CNS effect of the drug. Extrapyramidal reactions may occur with high doses; this is almost always responsive to a reduction in dosage. Other reported reactions include dizziness, lassitude, tinnitus, incoordination, fatigue, blurred vision, euphoria, diplopia, nervousness, insomnia, tremors, convulsive seizures, oculogyric crises, excitation, catatonic-like states, hysteria, and hallucinations.

Cardiovascular Effects

Tachycardia, bradycardia, faintness, dizziness, and increases and decreases in blood pressure have been reported following the use of promethazine hydrochloride (promethazine hydrochloride injection) . Venous thrombosis at the injection site has been reported. INTRA-ARTERIAL INJECTION MAY RESULT IN GANGRENE OF THE AFFECTED EXTREMITY. (See WARNINGS, Inadvertent Intra-arterial Injection.)

Gastrointestinal Effects

Nausea and vomiting have been reported, usually in association with surgical procedures and combination drug therapy.

Allergic Reactions

These include urticaria, dermatitis, asthma, and photosensitivity. Angioneurotic edema has been reported.

Other Reported Reactions

Leukopenia and agranulocytosis, usually when promethazine has been used in association with other known marrow-toxic agents, have been reported. Thrombocytopenic purpura and jaundice of the obstructive type have been associated with the use of promethazine. The jaundice is usually reversible on discontinuation of the drug. Subcutaneous injection has resulted in tissue necrosis. Nasal stuffiness may occur. Dry mouth has been reported.

Paradoxical Reactions (Overdosage)

Hyperexcitability and abnormal movements, which have been reported in pediatric patients following a single administration of promethazine hydrochloride (promethazine hydrochloride injection) , may be manifestations of relative overdosage, in which case, consideration should be given to the discontinuation of promethazine hydrochloride (promethazine hydrochloride injection) and to the use of other drugs. Respiratory depression, nightmares, delirium, and agitated behavior have also been reported in some of these patients.

Read the entire FDA prescribing information for Promethazine HCl Injection (Promethazine Hydrochloride Injection) »

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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