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Promethazine HCl Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Promethazine hydrochloride is used to treat or prevent nausea and vomiting caused by anesthesia or surgery, certain types of allergic reactions, pain caused by surgery or childbirth, and to sedate patients before surgery or medical procedures. Promethazine injection is usually given when a person cannot take the medication orally (by mouth). It is a phenothiazine. This medication is available in generic form. Common side effects include drowsiness, dizziness, tired feeling, ringing in the ears, problems with balance or coordination, blurred vision, feeling nervous or shaky, insomnia, skin rash or itching, dry mouth, or stuffy nose.
The average adult dose of promethazine hydrochloride is 25 mg. Promethazine hydrochloride may interact with cold or allergy medicine, sedatives, narcotics, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety, lithium, atropine, belladonna, benztropine, dimenhydrinate, methscopolamine, scopolamine, blood pressure medications, blood thinners, bronchodilators, bladder or urinary medications, MAO inhibitors, medicines to treat Parkinson's disease, restless leg syndrome, or pituitary gland tumor, or medicines to treat stomach ulcer or irritable bowel syndrome. Tell your doctor all medications and supplements you use. During pregnancy promethazine hydrochloride should be taken only if prescribed. It is unknown if it is harmful to a fetus. It is unknown if this drug passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.
Our promethazine hydrochloride Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Promethazine HCl FDA Prescribing Information: Side Effects
Central Nervous System
Drowsiness is the most prominent CNS effect of this drug. Sedation, somnolence, blurred vision, dizziness; confusion, disorientation, and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion; lassitude, tinnitus, incoordination, fatigue, euphoria, nervousness, diplopia, insomnia, tremors, convulsive seizures, excitation, catatonic-like states, hysteria. Hallucinations have also been reported.
Hyperexcitability and abnormal movements have been reported in patients following a single administration of promethazine HCl (promethazine hydrochloride) . Consideration should be given to the discontinuation of promethazine HCl (promethazine hydrochloride) and to the use of other drugs if these reactions occur. Respiratory depression, nightmares, delirium, and agitated behavior have also been reported in some of these patients.
Read the entire FDA prescribing information for Promethazine HCl (Promethazine Hydrochloride)
Additional Promethazine HCl Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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