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Promethazine HCl Suppositories

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Promethazine HCl Suppositories

Promethazine Hydrochloride Suppositories, USP
(promethazine hydrochloride suppositories)
12.5 mg and 25 mg

DRUG DESCRIPTION

Each rectal suppository contains 12.5 mg or 25 mg promethazine HCl with ascorbyl palmitate, silicon dioxide, white wax, and cocoa butter. Promethazine hydrochloride suppositories are for rectal administration only.

Promethazine HCl is a racemic compound; the empirical formula is C17H20N2S•HCl and its molecular weight is 320.88.

Promethazine HCl, a phenothiazine derivative, is designated chemically as 10H-Phenothiazine-10-ethanamine, N,N,α-trimethyl-, monohydrochloride, (±)- with the following structural formula:

Promethazine Hydrochloride Structural Formula Illustration

Promethazine HCl occurs as a white to faint yellow, practically odorless, crystalline powder which slowly oxidizes and turns blue on prolonged exposure to air. It is freely soluble in water and soluble in alcohol.

What are the possible side effects of rectal promethazine (Phenadoz, Promethegan)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using promethazine and call your doctor at once if you have any of these serious side effects:

  • twitching, or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
  • tremor (uncontrolled shaking), drooling, trouble swallowing, problems with balance or walking;
  • feeling restless, jittery, or agitated;
  • high fever, stiff muscles, confusion,...

Read All Potential Side Effects and See Pictures of Promethazine HCl Suppositories »

Last reviewed on RxList: 6/13/2008
This monograph has been modified to include the generic and brand name in many instances.

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