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Pronestyl

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Pronestyl

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

PRONESTYL
(procainamide hydrochloride) Capsule, Gelatin Coated

PRONESTYL
(procainamide hydrochloride) Tablet, Film Coated

Pronestyl

WARNING

The prolonged administration of procainamide often leads to the development of a positive antinuclear antibody (ANA) test, with or without symptoms of a lupus erythematosus-like syndrome. If a positive ANA titer develops, the benefits versus risks of continued procainamide therapy should be assessed.

DRUG DESCRIPTION

PRONESTYL (procainamide hydrochloride), a Group 1A cardiac antiarrhythmic drug, is p-amino-N-{2-(diethylamino)ethyl}-benzamide monohydrochloride, molecular weight 271.79; its graphic formula is:

PRONESTYL (procainamide hydrochloride) Structural Formula Illustration

What are the possible side effects of procainamide injection (Pronestyl)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have a serious side effect such as:

  • a new or a worsening irregular heartbeat pattern;
  • chest pain, wheezing, trouble breathing;
  • feeling like you might pass out;
  • signs of infection such as fever, chills, sore throat, flu symptoms, pale skin, easy bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, nausea and vomiting, sores in...

Read All Potential Side Effects and See Pictures of Pronestyl »

What are the precautions when taking procainamide (Pronestyl)?

Before taking procainamide, tell your doctor or pharmacist if you are allergic to it; or to local anesthetics (e.g., procaine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain heart problems (second- or third-degree atrioventricular block or bundle branch block unless you have a heart pacemaker), a certain immune problem (lupus).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: first-degree atrioventricular block, new or recent heart attack,...

Read All Potential Precautions of Pronestyl »

*(locus for acetylation to N-acetylprocainamide)

It differs from procaine which is the p-aminobenzoyl ester of 2-(diethylamino)-ethanol. Procainamide as the free base has a pKa of 9.23; the monohydrochloride is very soluble in water. PRONESTYL (procainamide hydrochloride) is supplied for oral administration as capsules and tablets in potencies of 250, 375, and 500 mg.

Inactive ingredients: Tablets—calcium silicate, microcrystalline cellulose, colorants (FD&C Yellow No. 5 (tartrazine) and Yellow No. 6), flavor, povidone, pregelatinized starch, stearic acid, and other ingredients.

Capsules—colorants (D&C Yellow No. 10, except 375 mg; FD&C Yellow No. 6), gelatin, lactose (except 500 mg); magnesium stearate, talc, and titanium dioxide.

What are the possible side effects of procainamide injection (Pronestyl)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have a serious side effect such as:

  • a new or a worsening irregular heartbeat pattern;
  • chest pain, wheezing, trouble breathing;
  • feeling like you might pass out;
  • signs of infection such as fever, chills, sore throat, flu symptoms, pale skin, easy bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, nausea and vomiting, sores in...

Read All Potential Side Effects and See Pictures of Pronestyl »

What are the precautions when taking procainamide (Pronestyl)?

Before taking procainamide, tell your doctor or pharmacist if you are allergic to it; or to local anesthetics (e.g., procaine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain heart problems (second- or third-degree atrioventricular block or bundle branch block unless you have a heart pacemaker), a certain immune problem (lupus).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: first-degree atrioventricular block, new or recent heart attack,...

Read All Potential Precautions of Pronestyl »

Last reviewed on RxList: 4/8/2009
This monograph has been modified to include the generic and brand name in many instances.

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