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Pronestyl

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Pronestyl

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Pronestyl

Pronestyl Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Pronestyl (procainamide hydrochloride) is used to help keep the heart beating normally in people with certain heart rhythm disorders of the ventricles (the lower chambers of the heart that allow blood to flow out of the heart). It is a cardiac antiarrhythmic drug. The brand name Pronestyl is discontinued in the U.S. Generic versions may be available. Common side effects include nausea, vomiting, loss of appetite, diarrhea, and bitter taste in the mouth.

The initial dose of procainamide for younger adult patients with normal renal function is up to 50 mg/kg of body weight per day taken orally in divided doses every three hours. Procainamide may interact with cimetidine, digoxin, or heart rhythm medications. Tell your doctor all medications you use. During pregnancy, procainamide should be used only when prescribed. This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

Our Pronestyl (procainamide hydrochloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Pronestyl in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have a serious side effect such as:

  • a new or a worsening irregular heartbeat pattern;
  • chest pain, wheezing, trouble breathing;
  • feeling like you might pass out;
  • signs of infection such as fever, chills, sore throat, flu symptoms, pale skin, easy bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, nausea and vomiting, sores in your mouth and throat, unusual weakness;
  • depressed mood, hallucinations, severe dizziness;
  • upper stomach pain, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • joint pain or swelling with fever, swollen glands, muscle pain or weakness, unusual thoughts or behavior, patchy skin color, red spots.

Less serious side effects may include:

  • mild dizziness or tired feeling;
  • flushing (warmth, redness, or tingly feeling); or
  • mild itching or rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Pronestyl (Procainamide) »

What is Patient Information Overview?

A concise overview of the drug for the patient or caregiver from First DataBank.

Pronestyl Overview - Patient Information: Side Effects

SIDE EFFECTS: Nausea, vomiting, loss of appetite, diarrhea, and bitter taste in the mouth may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication for a longer time may develop serious side effects, but with frequent visits to your doctor, this risk can be minimized. (See Warning section.)

Tell your doctor immediately if any of these unlikely but serious side effects occur: symptoms of liver problems (e.g., persistent nausea, stomach/abdominal pain, dark urine, yellowing eyes/skin), worsening symptoms of heart failure (e.g., ankle/leg swelling, increased tiredness, increased shortness of breath when lying down).

Seek immediate medical attention if any of these unlikely but serious side effects occur: severe dizziness, fainting, sudden change in heartbeat (unusually faster/slower/more irregular), chest pain.

Tell your doctor immediately if any of these rare but very serious side effects occur: seizures, mental/mood changes (e.g., depression, confusion, unusual thoughts/behavior, hallucinations), muscle pain/weakness, dry mouth/eyes.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the entire patient information overview for Pronestyl (Procainamide)»

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Pronestyl FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

Cardiovascular

Hypotension following oral PA administration is rare. Hypotension and serious disturbances of cardiorhythm such as ventricular asystole or fibrillation are more common after (see OVERDOSAGE, WARNINGS). Second degree heart block has been reported in 2 of almost 500 patients taking PA orally.

Multisystem

A lupus erythematosus-like syndrome of arthralgia, pleural or abdominal pain, and some-times arthritis, pleural effusion, pericarditis, fever, chills, myalgia, and possibly related hematologic or skin lesions (see below) is fairly common after prolonged PA administration, perhaps more often in patients who are slow acetylators (see Boxed WARNINGS and PRECAUTIONS). While some series have reported less than 1 in 500, others have reported the syndrome in up to 30 percent of patients on long term oral PA therapy. If discontinuation of PA does not reverse the lupoid symptoms, corticosteroid treatment may be effective.

Hematologic

Neutropenia, thrombocytopenia, or hemolytic anemia may rarely be encountered. Agranulocytosis has occurred after repeated use of PA, and deaths have been reported. (See Boxed WARNING, WARNINGS section.)

Skin

Angioneurotic edema, urticaria, pruritus, flushing, and maculopapular rash have also occurred occasionally.

Gastrointestinal

Anorexia, nausea, vomiting, abdominal pain, bitter taste, or diarrhea may occur in 3 to 4 percent of patients taking oral procainamide.

Elevated Liver Enzymes

Elevations of transaminase with and without elevations of alkaline phosphatase and bilirubin have been reported. Some patients have had clinical symptoms (e.g., malaise, right upper quadrant pain). Deaths from liver failure have been reported.

Nervous System

Dizziness or giddiness, weakness, mental depression, and psychosis with hallucinations have been reported occasionally.

Read the entire FDA prescribing information for Pronestyl (Procainamide) »

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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