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(dipivefrin hydrochloride) Ophthalmic Solution, USP 0.1% sterile


PROPINE® contains dipivefrin hydrochloride in a sterile, isotonic solution. Dipivefrin HCI is a white, crystalline powder, freely soluble in water.

Empirical Formula:


  (dipivefrin hydrochloride) Structural Formula Illustration

Chemical Name: () -3,4-Dihydroxy-α-[(methyl-amino) methyl] benzyl-alcohol 3,4-dipivalate hydrochloride.

Contains: Active: dipivefrin HCI 0.1%

Preservative: benzalkonium chloride; Inactives: edetate disodium; sodium chloride; hydrochloric acid to adjust pH; and purified water.

What are the possible side effects of dipivefrin ophthalmic (Propine)?

Stop using dipivefrin and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • severe stinging or burning in your eyes;
  • fast or uneven heart rate; or
  • high blood pressure (severe headache, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath).

Less serious side effects may include:

  • burning, stinging, or itching of your...

Read All Potential Side Effects and See Pictures of Propine »

What are the precautions when taking dipivefrin (Propine)?

Before using dipivefrin, tell your doctor or pharmacist if you are allergic to it; or to epinephrine; or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride, sulfites found in some brands), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: narrow or closed-angle glaucoma.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: eye problems (e.g., macular edema, lens extraction/aphakia), high blood pressure, heart or blood vessel disease, irregular...

Read All Potential Precautions of Propine »

Last reviewed on RxList: 11/18/2016
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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