Propranolol Hydrochloride Injection
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Propranolol Hydrochloride Injection
Propranolol Hydrochloride Injection Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Propranolol hydrochloride injection is a synthetic beta-adrenergic receptor blocking agent (beta-blocker) used to treat life-threatening arrhythmias or those occurring under anesthesia. This medication is available in generic form. Common side effects include low blood pressure, congestive heart failure, slow heart rate, heart block, and nausea.
The usual dose of propranolol hydrochloride is 1 to 3 mg administered under careful monitoring, such as electrocardiography and central venous pressure. Propranolol hydrochloride may interact with antiarrhythmic drugs, calcium channel blockers, ACE inhibitors, alpha-blockers, reserpine, epinephrine, dobutamine, isoproterenol, nonsteroidal anti-inflammatory drugs (NSAIDs), antidepressants, anesthetics, warfarin, propranolol, haloperidol, and thyroxine. Tell your doctor all medications and supplements you use. During pregnancy, propranolol hydrochloride should be used only if prescribed. Propranolol passes into breast milk. Consult your doctor before breastfeeding.
Our Propranolol hydrochloride injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Propranolol Hydrochloride Injection FDA Prescribing Information: Side Effects
In a series of 225 patients, there were 6 deaths (see Clinical Studies). Cardiovascular events (hypotension, congestive heart failure, bradycardia, and heart block) were the most common. The only other event reported by more than one patient was nausea.
The following adverse events have been reported with use of formulations of sustained- or immediate-release oral propranolol and may be expected with intravenous propranolol.
Central Nervous System
Light-headedness; mental depression manifested by insomnia, lassitude, weakness, fatigue; reversible mental depression progressing to catatonia; visual disturbances; hallucinations; vivid dreams; an acute reversible syndrome characterized by disorientation for time and place, short-term memory loss, emotional lability, slightly clouded sensorium, and decreased performance on neuropsychometrics. For immediate-release formulations, fatigue, lethargy, and vivid dreams appear dose related.
Nausea, vomiting, epigastric distress, abdominal cramping, diarrhea, constipation, mesenteric arterial thrombosis, ischemic colitis.
Agranulocytosis, nonthrombocytopenic purpura, thrombocytopenic purpura.
In extremely rare instances, systemic lupus erythematosus has been reported.
Alopecia, LE-like reactions, psoriaform rashes, dry eyes, male impotence, and Peyronie's disease have been reported rarely. Oculomucocutaneous reactions involving the skin, serous membranes and conjunctivae reported for a beta-blocker (practolol) have not been associated with propranolol.
Read the entire FDA prescribing information for Propranolol Hydrochloride Injection (Propranolol Hydrochloride Injection)
Additional Propranolol Hydrochloride Injection Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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