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Propylthiouracil

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Propylthiouracil

CLINICAL PHARMACOLOGY

Propylthiouracil (propylthiouracil (propylthiouracil (propylthiouracil tablet) tablet) tablet) inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. The drug does not inactivate existing thyroxine and triodothyronine that are stored in the thyroid or circulating in the blood, nor does it interfere with the effectiveness of thyroid hormones given by mouth or by injection.

Propylthiouracil (propylthiouracil (propylthiouracil (propylthiouracil tablet) tablet) tablet) is readily absorbed from the gastrointestinal tract. It is metabolized rapidly and requires frequent administration. Approximately 35% of the drug is excreted in the urine, in intact and in conjugated forms, within 24 hours.

In laboratory animals, various interventions, including propylthiouracil (propylthiouracil (propylthiouracil (propylthiouracil tablet) tablet) tablet) administration, that continuously suppress thyroid function and thereby increase TSH secretion result in thyroid tissue hypertrophy.

Last reviewed on RxList: 1/25/2010
This monograph has been modified to include the generic and brand name in many instances.

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