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(neostigmine bromide) Tablets


Prostigmin (neostigmine bromide), an anticholinesterase agent, is available for oral administration in 15 mg tablets. Each tablet also contains gelatin, lactose, corn starch, stearic acid, sugar and talc.

Chemically, neostigmine bromide is (m-hydroxyphenyl) trimethylammonium bromide dimethylcarbamate. It is a white, crystalline, bitter powder, soluble 1:1 in water, with a molecular weight of 303.20 and the following structural formula:

  (neostigmine bromide) Structural Formula Illustration

What are the possible side effects of neostigmine (Prostigmin Bromide)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using neostigmine and call your doctor at once if you have any of these serious side effects:

  • extreme muscle weakness;
  • slurred speech, vision problems;
  • feeling like you might pass out;
  • severe stomach cramps or diarrhea;
  • trouble breathing, cough with mucus;
  • fast or slow heart rate;
  • seizure (convulsions); or
  • worsening or no improvement in...

Read All Potential Side Effects and See Pictures of Prostigmin »

What are the precautions when taking neostigmine (Prostigmin)?

Before taking neostigmine, tell your doctor or pharmacist if you are allergic to it; or to other anticholinesterase medications (e.g., pyridostigmine); or to bromides; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: stomach/intestinal blockage, urinary blockage, a certain abdominal problem (peritonitis).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: seizures, asthma, heart disease (e.g., slow/irregular heartbeat, coronary artery disease), a...

Read All Potential Precautions of Prostigmin »

Last reviewed on RxList: 3/26/2009
This monograph has been modified to include the generic and brand name in many instances.

Prostigmin - User Reviews

Prostigmin User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Prostigmin sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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