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Prostigmin

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Prostigmin

Prostigmin Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Prostigmin (neostigmine) is used to treat the symptoms of myasthenia gravis. It is an anticholinesterase agent. This medication may be available in generic form. Common side effects include nausea, vomiting, diarrhea, abdominal cramps, increased saliva/mucus, decreased pupil size, increased urination, or increased sweating.

Dosage requirements of Prostigmin for optimal results vary from 15 mg to 375 mg per day. Prostigmin may interact with atropine, belladonna, clidinium, dicyclomine, glycopyrrolate, hyoscyamine, mepenzolate, methantheline, methscopolamine, propantheline, scopolamine, antibiotics, or heart rhythm medications. Tell your doctor all medications you use. During pregnancy, Prostigmin should be used only when prescribed. It is unknown if this drug passes into breast milk. Similar drugs pass into breast milk. Consult your doctor before breast-feeding.

Our Prostigmin (neostigmine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Prostigmin in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using neostigmine and call your doctor at once if you have any of these serious side effects:

  • extreme muscle weakness;
  • slurred speech, vision problems;
  • feeling like you might pass out;
  • severe stomach cramps or diarrhea;
  • trouble breathing, cough with mucus;
  • fast or slow heart rate;
  • seizure (convulsions); or
  • worsening or no improvement in your symptoms of myasthenia gravis.

Less serious side effects may include:

  • headache, drowsiness;
  • mild nausea, vomiting, gas;
  • urinating more than usual;
  • cold sweat, warmth or tingly feeling; or
  • mild rash or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Prostigmin (Neostigmine) »

What is Patient Information Overview?

A concise overview of the drug for the patient or caregiver from First DataBank.

Prostigmin Overview - Patient Information: Side Effects

SIDE EFFECTS: Nausea, vomiting, diarrhea, abdominal cramps, increased saliva/mucus, decreased pupil size, increased urination, or increased sweating may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: new or increased muscle cramps/weakness/twitching, new or increased difficulty swallowing, slow/fast/irregular heartbeat, dizziness, shortness of breath, headache, seizures.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the entire patient information overview for Prostigmin (Neostigmine)»

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Prostigmin FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

Side effects are generally due to an exaggeration of pharmacological effects of which salivation and fasciculation are the most common. Bowel cramps and diarrhea may also occur.

The following additional adverse reactions have been reported following the use of either neostigmine bromide or neostigmine methylsulfate:

Allergic: Allergic reactions and anaphylaxis.

Neurologic: Dizziness, convulsions, loss of consciousness, drowsiness, headache, dysarthria, miosis and visual changes.

Cardiovascular: Cardiac arrhythmias (including bradycardia, tachycardia, A-V block and nodal rhythm) and nonspecific EKG changes have been reported, as well as cardiac arrest, syncope and hypotension. These have been predominantly noted following the use of the injectable form of Prostigmin (neostigmine) .

Respiratory: Increased oral, pharyngeal and brochial secretions, and dyspnea. Respiratory depression, respiratory arrest and bronchospasm have been reported following the use of the injectable form of Prostigmin (neostigmine) .

Dermatologic: Rash and urticaria.

Gastrointestinal: Nausea, emesis, flatulence and increased peristalsis.

Genitourinary: Urinary frequency.

Musculoskeletal: Muscle cramps and spasms, arthralgia.

Miscellaneous: Diaphoresis, flushing and weakness.

Read the entire FDA prescribing information for Prostigmin (Neostigmine) »

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Prostigmin - User Reviews

Prostigmin User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Prostigmin sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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