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Prostin E2

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Prostin E2

Prostin E2®
(dinoprostone) Vaginal Suppository

DRUG DESCRIPTION

PROSTIN E2 Vaginal Suppository, an oxytocic, contains dinoprostone as the naturally occurring prostaglandin E2 (PGE2).

Its chemical name is (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1-oic acid and the structural formula is represented below:

Prostin E2® 
  (dinoprostone) Structural Formula Illustration

The molecular formula is C20H32O5. The molecular weight of dinoprostone is 352.5.

Dinoprostone occurs as a white crystalline powder. It has a melting point within the range of 64° to 71°C. Dinoprostone is soluble in ethanol and in 25% ethanol in water. It is soluble in water to the extent of 130 mg/100 mL.

Each suppository contains 20 mg of dinoprostone in a mixture of glycerides of fatty acids.

What are the possible side effects of dinoprostone topical (Cervidil, Prepidil, Prostin E2)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if your contractions slow down or become uneven, or if you have:

  • fever;
  • sudden vaginal bleeding;
  • cough, wheezing, chest tightness, trouble breathing; or
  • pale skin, blue colored lips.

After your baby is born, seek emergency medical attention if you have any signs of excessive bleeding, such...

Read All Potential Side Effects and See Pictures of Prostin E2 »

What are the precautions when taking dinoprostone vaginal suppository (Prostin E2)?

Before using this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe breathing problem (e.g., uncontrolled asthma), current pelvic problem (active pelvic inflammatory disease), current heart disease (e.g., uncontrolled angina, recent heart attack), liver disease, kidney disease.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: anemia, asthma, high or low blood pressure,...

Read All Potential Precautions of Prostin E2 »

Last reviewed on RxList: 10/7/2008
This monograph has been modified to include the generic and brand name in many instances.

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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