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- Patient Information:
Details with Side Effects
- PROSTIN E2 (dinoprostone vaginal suppository) Vaginal Suppository is indicated for the termination of pregnancy from the 12th through the 20th gestational week as calculated from the first day of the last normal menstrual period.
- PROSTIN E2 (dinoprostone vaginal suppository) is also indicated for evacuation of the uterine contents in the management of missed abortion or intrauterine fetal death up to 28 weeks of gestational age as calculated from the first day of the last normal menstrual period.
- PROSTIN E2 (dinoprostone vaginal suppository) is indicated in the management of nonmetastatic gestational trophoblastic disease (benign hydatidiform mole).
DOSAGE AND ADMINISTRATION
STORE IN A FREEZER NOT ABOVE –20°C (–4°F) BUT BRING TO ROOM TEMPERATURE JUST PRIOR TO USE.
REMOVE FOIL BEFORE USE.
A suppository containing 20 mg of dinoprostone should be inserted high into the vagina. The patient should remain in the supine position for ten minutes following insertion. Additional intravaginal administration of each subsequent suppository should be at 3- to 5-hour intervals until abortion occurs. Within the above recommended intervals administration time should be determined by abortifacient progress, uterine contractility response, and by patient tolerance. Continuous administration of the drug for more than 2 days is not recommended.
PROSTIN E2 (dinoprostone vaginal suppository) Vaginal Suppositories are available in foil strips of 5 individually sealed suppositories, NDC 0009-0827-03. Each suppository contains 20 mg of dinoprostone in a mixture of glycerides of fatty acids.
STORE IN A FREEZER NOT ABOVE –20°C (–4°F).
Distributed by: Pharmacia and Upjohn Company, Division of Pfizer Inc, NY, NY 10017. Revised April 2006. FDA Rev date: 11/19/1997
Last reviewed on RxList: 10/7/2008
This monograph has been modified to include the generic and brand name in many instances.
Additional Prostin E2 Information
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