August 30, 2016
Recommended Topic Related To:

Prostin E2

"Daily maternal consumption of artificially sweetened beverages (ASBs) during pregnancy was linked to a 0.20-unit rise in infant body mass index (BMI) z score and a twofold higher risk for overweight, according to a new study of 2413 mother"...

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Prostin E2




Side Effects
Interactions

SIDE EFFECTS

The most frequent adverse reactions observed with the use of dinoprostone for abortion are related to its contractile effect on smooth muscle.

In the patients studied, approximately two-thirds experienced vomiting, one-half temperature elevations, two-fifths diarrhea, one-third some nausea, one-tenth headache, and one-tenth shivering and chills.

In addition, approximately one-tenth of the patients studied exhibited transient diastolic blood pressure decreases of greater than 20 mmHg.

Two cases of myocardial infarction following the use of dinoprostone have been reported in patients with a history of cardiovascular disease.

It is not known whether these events were related to the administration of dinoprostone.

Adverse effects in decreasing order of their frequency, observed with the use of dinoprostone, not all of which are clearly drug related include:

Vomiting
Diarrhea
Nausea
Fever
Headache
Chills or shivering
Backache
Joint inflammation or pain new or exacerbated
Flushing or hot flashes
Dizziness
Arthralgia
Vaginal pain
Chest pain
Dyspnea
Endometritis
Syncope or fainting sensation
Vaginitis or vulvitis
Weakness
Muscular cramp or pain
Tightness in chest
Nocturnal leg cramps
Uterine rupture
Breast tenderness
Blurred vision
Coughing
Rash
Myalgia
Stiff neck
Dehydration
Tremor
Paresthesia
Hearing impairment
Urine retention
Pharyngitis
Laryngitis
Diaphoresis
Eye pain
Wheezing
Cardiac arrhythmia
Skin discoloration
Vaginismus
Tension

Post-Marketing Surveillance

Immune system disorders: Hypersensitivity reactions (e.g., Anaphylactic reaction, Anaphylactic shock, Anaphylactoid reaction).

Read the Prostin E2 (dinoprostone vaginal suppository) Side Effects Center for a complete guide to possible side effects

DRUG INTERACTIONS

PROSTIN E2 may augment the activity of other oxytocic drugs. Concomitant use with other oxytocic agents is not recommended.

Read the Prostin E2 Drug Interactions Center for a complete guide to possible interactions

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 6/13/2016

Side Effects
Interactions

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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