Prostin E2
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Prostin E2
SIDE EFFECTS
The most frequent adverse reactions observed with the use of dinoprostone for abortion are related to its contractile effect on smooth muscle.
In the patients studied, approximately two-thirds experienced vomiting, one-half temperature elevations, two-fifths diarrhea, one-third some nausea, one-tenth headache, and one-tenth shivering and chills.
In addition, approximately one-tenth of the patients studied exhibited transient diastolic blood pressure decreases of greater than 20 mmHg.
Two cases of myocardial infarction following the use of dinoprostone have been reported in patients with a history of cardiovascular disease.
It is not known whether these events were related to the administration of dinoprostone.
Adverse effects in decreasing order of their frequency, observed with the use of dinoprostone, not all of which are clearly drug related include:
| Vomiting | Nocturnal leg cramps |
| Diarrhea | Uterine rupture |
| Nausea | Breast tenderness |
| Fever | Blurred vision |
| Headache | Coughing |
| Chills or shivering | Rash |
| Backache | Myalgia |
| Joint inflammation or | Stiff neck |
| pain new or | Dehydration |
| exacerbated | Tremor |
| Flushing or hot flashes | Paresthesia |
| Dizziness | Hearing impairment |
| Arthralgia | Urine retention |
| Vaginal pain | Pharyngitis |
| Chest pain | Laryngitis |
| Dyspnea | Diaphoresis |
| Endometritis | Eye pain |
| Syncope or fainting | Wheezing |
| sensation | Cardiac arrhythmia |
| Vaginitis or vulvitis | Skin discoloration |
| Weakness | Vaginismus |
| Muscular cramp or pain | Tension |
| Tightness in chest |
Read the Prostin E2 (dinoprostone vaginal suppository) Side Effects Center for a complete guide to possible side effects »
DRUG INTERACTIONS
PROSTIN E2 (dinoprostone vaginal suppository) may augment the activity of other oxytocic drugs. Concomitant use with other oxytocic agents is not recommended.
Last reviewed on RxList: 10/7/2008
This monograph has been modified to include the generic and brand name in many instances.
Additional Prostin E2 Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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