July 23, 2016
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Prostin VR Pediatric

"Cases of a serious birth defect of the abdominal wall called gastroschisis continues to increase over time, according to a report in CDC's Morbidity and Mortality Weekly Report. CDC researchers found that over 18 years, the prevalence of gastrosc"...

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Prostin VR Pediatric

Prostin VR Pediatric®
(alprostadil) Injection, USP
500 micrograms per mL




WARNING

Apnea is experienced by about 10 to 12% of neonates with congenital heart defects treated with PROSTIN VR PEDIATRIC Sterile Solution. Apnea is most often seen in neonates weighing less than 2 kg at birth and usually appears during the first hour of drug infusion. Therefore, respiratory status should be monitored throughout treatment, and PROSTIN VR PEDIATRIC should be used where ventilatory assistance is immediately available.

DRUG DESCRIPTION

PROSTIN VR PEDIATRIC Sterile Solution for intravascular infusion contains 500 micrograms alprostadil, more commonly known as prostaglandin E1, in 1.0 mL dehydrated alcohol.

The chemical name for alprostadil is (11α,13E,15S)-11,15 dihydroxy-9-oxo-prost-13-en-1-oic acid, and the molecular weight is 354.49.

Alprostadil is a white to off-white crystalline powder with a melting point between 110° and 116°C. Its solubility at 35°C is 8000 micrograms per 100 mL double distilled water. Structural Formula

Prostin VR Pediatric® (alprostadil) Structural Formula Illustration

What are the possible side effects of alprostadil (Caverject, Caverject Impulse, Edex, Muse)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using alprostadil and call your doctor at once if you have a serious side effect such as:

  • feeling light-headed, fainting;
  • trouble urinating, blood in your urine;
  • bleeding, bruising, or swelling where you injected the medication;
  • a painful erection that lasts 4 hours or longer;
  • severe pain or irritation of your penis or urethra;...

Read All Potential Side Effects and See Pictures of Prostin VR Pediatric »

Last reviewed on RxList: 6/13/2016
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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