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Prostin VR Pediatric

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Prostin VR Pediatric

SIDE EFFECTS

Prostin VR Pediatric (alprostadil) Sterile Solution

Central Nervous System Apnea has been reported in about 12% of the neonates treated. (See BOXED WARNING.) Other common adverse reactions reported have been fever in about 14% of the patients treated and seizures in about 4%. The following reactions have been reported in less than 1% of the patients: cerebral bleeding, hyperextension of the neck, hyperirritability, hypothermia, jitteriness, lethargy, and stiffness.

    Cardiovascular System: The most common adverse reactions reported have been flushing in about 10% of patients (more common after intraarterial dosing), bradycardia in about 7%, hypotension in about 4%, tachycardia in about 3%, cardiac arrest in about 1%, and edema in about 1%. The following reactions have been reported in less than 1% of the patients: congestive heart failure, hyperemia, second degree heart block, shock, spasm of the right ventricle infundibulum, supraventricular tachycardia, and ventricular fibrillation.

    Respiratory System: The following reactions have been reported in less than 1% of the patients: bradypnea, bronchial wheezing, hypercapnia, respiratory depression, respiratory distress, and tachypnea.

    Gastrointestinal System: See WARNINGS. The most common adverse reaction reported has been diarrhea in about 2% of the patients. The following reactions have been reported in less than 1% of the patients: gastric regurgitation, and hyperbilirubinemia.

    Hematologic System: The most common hematologic event reported has been disseminated intravascular coagulation in about 1% of the patients. The following events have been reported in less than 1% of the patients: anemia, bleeding, and thrombocytopenia.

    Excretory System: Anuria and hematuria have been reported in less than 1% of the patients.

    Skeletal System: Cortical proliferation of the long bones has been reported. See PRECAUTIONS.

    Miscellaneous: Sepsis has been reported in about 2% of the patients. Peritonitis has been reported in less than 1% of the patients. Hypokalemia has been reported in about 1% and hypoglycemia and hyperkalemia have been reported in less than 1% of the patients.

Read the Prostin VR Pediatric (alprostadil) Side Effects Center for a complete guide to possible side effects

DRUG INTERACTIONS

Prostin VR Pediatric (alprostadil) Sterile Solution

No drug interactions have been reported between Prostin VR Pediatric (alprostadil) and the therapy standard in neonates with restricted pulmonary or systemic blood flow. Standard therapy includes antibiotics, such as penicillin and gentamicin; vasopressors, such as dopamine and isoproterenol; cardiac glycosides; and diuretics, such as furosemide.

Read the Prostin VR Pediatric Drug Interactions Center for a complete guide to possible interactions

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

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