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Protamine Drug Center

Protamine Sulfate (protamines) is indicated in the treatment of heparin (a drug used to treat and prevent blood clots) overdose. It is a heparin antagonist. It is also a weak anticoagulant. Common side effects include sudden fall in blood pressure, bradycardia, pulmonary hypertension, dyspnea, or flushing and a feeling of warmth. There have been reports of anaphylaxis that resulted in respiratory difficulty, systemic hypertension, nausea, vomiting and fatigue.

Protamine Sulfate is administered by a doctor and is given by very slow intravenous (IV) injection in doses not to exceed 50 mg in any 10-minute period. Protamine sulfate may interact with certain antibiotics, including several of the cephalosporins and penicillins. Tell your doctor all medications you are taking. Protamine sulfate should be given to a pregnant woman only if prescribed. It is not known whether this drug passes into breast milk. Consult a doctor before breast-feeding.

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