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Protamine Sulfate (protamine (protamines) s) Injection, USP is a sterile, non-pyrogenic, isotonic solution of protamine sulfate (protamine (protamines) s) in Water for Injection. It acts as a heparin antagonist. It is also a weak anticoagulant.

Protamine (protamines) s are simple protein principles obtained from the sperm of salmon and certain other species of fish. Protamine (protamines) s have low molecular weight, are rich in arginine, and are strongly basic.

Protamine sulfate (protamine (protamines) s) occurs as fine white or off-white amorphous or crystalline powder. It is sparingly soluble in water. The pH is between 6 and 7. The cationic hydrogenated protamine (protamines) at a pH of 6.8 to 7.1 reacts with anionic heparin at a pH of 5.0 to 7.5 to form an inactive complex.

Each mL contains

Protamine sulfate (protamine (protamines) s) 10 mg, sodium chloride 9 mg and Water for Injection q.s. Sulfuric acid and/or dibasic sodium phosphate (heptahydrate) may have been added for pH adjustment.

The preparation is preservative free.

Protamine sulfate (protamine (protamines) s) is administered intravenously.

Last reviewed on RxList: 11/21/2008
This monograph has been modified to include the generic and brand name in many instances.