"Sometimes the juice ain't worth the squeeze... especially when combining grapefruit with medicines.
While it can be part of a balanced and nutritious diet, grapefruit can have serious consequences when taken with certain medications. Cu"...
When administered alone, protamine (protamines) has an anticoagulant effect. However, when it is given in the presence of heparin (which is strongly acidic), a stable salt is formed which results in the loss of anticoagulant activity of both drugs.
Protamine sulfate (protamine (protamines) s) has a rapid onset of action.
Neutralization of heparin occurs within five minutes after intravenous administration. Although the metabolic fate of the heparin-protamine (protamines) complex has not been elucidated, it has been postulated that protamine sulfate (protamine (protamines) s) in the heparin-protamine (protamines) complex may be partially metabolized or may be attacked by fibrinolysin, thus freeing heparin.
Last reviewed on RxList: 11/21/2008
This monograph has been modified to include the generic and brand name in many instances.
Additional Protamine Information
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