Recommended Topic Related To:

Protamine

"A unique type of poster placed in exam rooms helped reduce unnecessary antibiotic prescriptions for respiratory infections during flu season. The approach could help reduce costs and extend the usefulness of these drugs.

Antibiotics a"...

Protamine

CLINICAL PHARMACOLOGY

When administered alone, protamine (protamines) has an anticoagulant effect. However, when it is given in the presence of heparin (which is strongly acidic), a stable salt is formed which results in the loss of anticoagulant activity of both drugs.

Protamine sulfate (protamine (protamines) s) has a rapid onset of action.

Neutralization of heparin occurs within five minutes after intravenous administration. Although the metabolic fate of the heparin-protamine (protamines) complex has not been elucidated, it has been postulated that protamine sulfate (protamine (protamines) s) in the heparin-protamine (protamines) complex may be partially metabolized or may be attacked by fibrinolysin, thus freeing heparin.

Last reviewed on RxList: 11/21/2008
This monograph has been modified to include the generic and brand name in many instances.

A A A

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Women's Health

Find out what women really need.

advertisement
advertisement
Use Pill Finder Find it Now See Interactions

Pill Identifier on RxList

  • quick, easy,
    pill identification

Find a Local Pharmacy

  • including 24 hour, pharmacies

Interaction Checker

  • Check potential drug interactions
Search the Medical Dictionary for Health Definitions & Medical Abbreviations