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Because of the anticoagulant effect of protamine sulfate (protamine (protamines) s) , overdosage of this drug may theoretically result in hemorrhage.However, in one study, overdosage of 600 to 800 mg of intravenous protamine sulfate (protamine (protamines) s) had only minimal, transient effects on blood coagulation tests.The patient should be followed with coagulation studies and treated symptomatically.

The LD₅₀ of protamine sulfate (protamine (protamines) s) is 100 mg/kg in mice.

Protamine sulfate (protamine (protamines) s) is contraindicated in patients who have shown previous intolerance to the drug.

Last reviewed on RxList: 11/21/2008
This monograph has been modified to include the generic and brand name in many instances.