February 14, 2016
Recommended Topic Related To:

Protamine

"The U.S. Food and Drug Administration today granted accelerated approval to Praxbind (idarucizumab) for use in patients who are taking the anticoagulant Pradaxa (dabigatran) during emergency situations when there is a need to reverse Pradaxa&rsqu"...

A A A

Protamine

Overdosage
Contraindications

OVERDOSE

Because of the anticoagulant effect of protamine sulfate (protamine (protamines) s) , overdosage of this drug may theoretically result in hemorrhage.However, in one study, overdosage of 600 to 800 mg of intravenous protamine sulfate (protamine (protamines) s) had only minimal, transient effects on blood coagulation tests.The patient should be followed with coagulation studies and treated symptomatically.

The LD50 of protamine sulfate (protamine (protamines) s) is 100 mg/kg in mice.

CONTRAINDICATIONS

Protamine sulfate (protamine (protamines) s) is contraindicated in patients who have shown previous intolerance to the drug.

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 11/21/2008

Overdosage
Contraindications

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Women's Health

Find out what women really need.

Use Pill Finder Find it Now See Interactions

Pill Identifier on RxList

  • quick, easy,
    pill identification

Find a Local Pharmacy

  • including 24 hour, pharmacies

Interaction Checker

  • Check potential drug interactions
Search the Medical Dictionary for Health Definitions & Medical Abbreviations