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The esophagus is a tube that connects the mouth to the stomach. It is made of muscles that work to push food toward the stomach in rhythmic waves. Once in the stomach, food is prevented from refluxing (moving back into the esophagus), by a special area of circular muscle located at the junction of the esophagus and stomach, called the lower esophageal sphincter (LES). A pressure difference across the diaphragm, the flat muscle that separates the chest from the abdomen, also tends to keep stomach contents in the stomach.
The stomach combines food, acids, and enzymes together to begin digestion. There are special protective cells that line the stomach to prevent the acid from causing inflammation. The esophagus does not have this same protection; if stomach products reflux back into the esophagus, they can cause inflammation to the lining.
Heartburn is actually a symptom of G...
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Medical Editor: Melissa Conrad Stöppler, MD
Protonix (pantoprazole) is a medication in the proton-pump inhibitor (PPI) class used to treat esophagitis associated with gastroesophageal reflux disease (GERD). Protonix is supplied as delayed-release granules in packets for preparation of oral suspensions or as delayed-release tablets. Common side effects of Protonix include headache, diarrhea, nausea, and abdominal pain.
Long-term treatment with Protonix may make it harder for your body to absorb vitamin B-12, resulting in a deficiency of this vitamin. In long-term rodent studies, pantoprazole was carcinogenic and caused rare types of gastrointestinal tumors. The relevance of these findings to tumor development in humans is unknown. Animal studies showed no harm during pregnancy; however there are no adequate and well-controlled studies in pregnant women, and this drug should be used during pregnancy only if clearly needed. Pantoprazole and its metabolites are excreted in the milk of rats. Based on the potential for tumorigenicity shown for pantoprazole in rodent carcinogenicity studies, a decision should be made whether to discontinue nursing or to discontinue the drug.
Our Protonix Drug Center provides a comprehensive view of available drug information as well as related drugs, user reviews, supplements and disease and conditions.
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
PROTONIX For Delayed-Release Oral Suspension and PROTONIX Delayed-Release Tablets are indicated for:
PROTONIX is indicated in adults and pediatric patients five years of age and older for the short-term treatment (up to 8 weeks) in the healing and symptomatic relief of erosive esophagitis. For those adult patients who have not healed after 8 weeks of treatment, an additional 8-week course of PROTONIX may be considered. Safety of treatment beyond 8 weeks in pediatric ...
Read the complete drug monograph for Protonix »
Drug Description - Indications & Dosage - Side Effects & Drug Interactions - Warnings & Precautions - Contraindications - Medication Guide and More
What is Patient information?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Less serious side effects are more likely to occur, such as:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Read the complete patient information for Protonix »
Possible Side Effects - Images - What Is - How Should I Take It - What If I Miss a Dose - What Should I Avoid and More
What is Consumer information?
A concise overview of the drug for the patient or caregiver from First DataBank.
OTHER USES: This section contains uses of this drug that are not listed in the approved US profess...
Read the complete consumer information for Protonix »
Warnings - Uses - How to Use - Side Effects - Precautions - Drug Interactions and More
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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