"What are antacids, and how do they work?
Antacids are a class of drugs used to treat conditions caused by the acid that is produced by the stomach. The stomach naturally secretes an acid called hydrochloric acid that helps to break "...
Experience in patients taking very high doses of PROTONIX ( > 240 mg) is limited. Spontaneous post-marketing reports of overdose are generally within the known safety profile of PROTONIX.
Pantoprazole is not removed by hemodialysis. In case of overdosage, treatment should be symptomatic and supportive.
Single oral doses of pantoprazole at 709 mg/kg, 798 mg/kg, and 887 mg/kg were lethal to mice, rats, and dogs, respectively. The symptoms of acute toxicity were hypoactivity, ataxia, hunched sitting, limb-splay, lateral position, segregation, absence of ear reflex, and tremor.
PROTONIX is contraindicated in patients with known hypersensitivity to any component of the formulation [see DESCRIPTION or any substituted benzimidazole.
Last reviewed on RxList: 12/19/2013
This monograph has been modified to include the generic and brand name in many instances.
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